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dc.contributor.authorShaw, CJen_US
dc.contributor.authorCivale, Jen_US
dc.contributor.authorBotting, KJen_US
dc.contributor.authorNiu, Yen_US
dc.contributor.authorTer Haar, Gen_US
dc.contributor.authorRivens, Ien_US
dc.contributor.authorGiussani, DAen_US
dc.contributor.authorLees, CCen_US
dc.date.accessioned2018-01-31T11:03:23Z
dc.date.issued2016-07en_US
dc.identifier.citationScience translational medicine, 2016, 8 (347), pp. 347ra95 - ?en_US
dc.identifier.issn1946-6234en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1041
dc.identifier.eissn1946-6242en_US
dc.identifier.doi10.1126/scitranslmed.aaf2135en_US
dc.description.abstractWe investigated the efficacy, maternofetal responses, and safety of using high-intensity focused ultrasound (HIFU) for noninvasive occlusion of placental vasculature compared to sham treatment in anesthetized pregnant sheep. This technique for noninvasive occlusion of placental vasculature may be translatable to the treatment of conditions arising from abnormal placental vasculature, such as twin-twin transfusion syndrome (TTTS). Eleven pregnant sheep were instrumented with maternal and fetal arterial catheters and time-transit flow probes to monitor cardiovascular, acid-base, and metabolic status, and then exposed to HIFU (n = 5) or sham (n = 6) ablation of placental vasculature through the exposed uterine surface. Placental vascular flow was occluded in 28 of 30 targets, and histological examination confirmed occlusion in 24 of 30 targets. In both HIFU and sham exposures, uterine contact reduced maternal uterine artery flow, but delivery of oxygen and glucose to the fetal brain remained normal. HIFU can consistently occlude in vivo placental vessels and ablate blood flow in a pregnant sheep model. Cardiovascular and metabolic fetal responses suggest that the technique is safe in the short term and potentially translatable to human pregnancy.en_US
dc.formatPrinten_US
dc.format.extent347ra95 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectBrainen_US
dc.subjectFetusen_US
dc.subjectAnimalsen_US
dc.subjectSheepen_US
dc.subjectFetofetal Transfusionen_US
dc.subjectOxygenen_US
dc.subjectGlucoseen_US
dc.subjectPregnancyen_US
dc.subjectFemaleen_US
dc.subjectHigh-Intensity Focused Ultrasound Ablationen_US
dc.titleNoninvasive high-intensity focused ultrasound treatment of twin-twin transfusion syndrome: A preliminary in vivo study.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-06-13en_US
rioxxterms.versionofrecord10.1126/scitranslmed.aaf2135en_US
rioxxterms.licenseref.startdate2016-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfScience translational medicineen_US
pubs.issue347en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Imaging for Radiotherapy Adaptation
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.publication-statusPublisheden_US
pubs.volume8en_US
pubs.embargo.termsNot knownen_US
icr.researchteamImaging for Radiotherapy Adaptationen_US
icr.researchteamTherapeutic Ultrasounden_US
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthorRivens, Ianen_US
dc.contributor.icrauthorCivale, Johnen_US
dc.contributor.icrauthorTer Haar, Gailen_US


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