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dc.contributor.authorLee, Y-F
dc.contributor.authorRoe, T
dc.contributor.authorMangham, DC
dc.contributor.authorFisher, C
dc.contributor.authorGrimer, RJ
dc.contributor.authorJudson, I
dc.date.accessioned2016-09-28T10:36:18Z
dc.date.issued2016-10
dc.identifier.citationBritish journal of cancer, 2016, 115 (8), pp. 1000 - 1007
dc.identifier.issn0007-0920
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/126
dc.identifier.eissn1532-1827
dc.identifier.doi10.1038/bjc.2016.280
dc.description.abstractBackground Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Although defined as a single group, they exhibit a wide range of clinical behaviour. We aimed to carry out molecular classification to identify new molecular subgroups with clinical relevance.Methods We used gene expression profiling on 20 extra-uterine leiomyosarcomas and cross-study analyses for molecular classification of leiomyosarcomas. Clinical significance of the subgroupings was investigated.Results We have identified two distinct molecular subgroups of leiomyosarcomas. One group was characterised by high expression of 26 genes that included many genes from the sub-classification gene cluster proposed by Nielsen et al. These sub-classification genes include genes that have importance structurally, as well as in cell signalling. Notably, we found a statistically significant association of the subgroupings with tumour grade. Further refinement led to a group of 15 genes that could recapitulate the tumour subgroupings in our data set and in a second independent sarcoma set. Remarkably, cross-study analyses suggested that these molecular subgroups could be found in four independent data sets, providing strong support for their existence.Conclusions Our study strongly supported the existence of distinct leiomyosarcoma molecular subgroups, which have clinical association with tumour grade. Our findings will aid in advancing the classification of leiomyosarcomas and lead to more individualised and better management of the disease.
dc.formatPrint-Electronic
dc.format.extent1000 - 1007
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectExtremities
dc.subjectHumans
dc.subjectLeiomyosarcoma
dc.subjectAbdominal Neoplasms
dc.subjectRetroperitoneal Neoplasms
dc.subjectThoracic Neoplasms
dc.subjectNeoplasm Proteins
dc.subjectTissue Array Analysis
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectNeoplasm Grading
dc.subjectDatasets as Topic
dc.titleGene expression profiling identifies distinct molecular subgroups of leiomyosarcoma with clinical relevance.
dc.typeJournal Article
dcterms.dateAccepted2016-08-09
rioxxterms.versionofrecord10.1038/bjc.2016.280
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-10
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBritish journal of cancer
pubs.issue8
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials
pubs.publication-statusPublished
pubs.volume115en_US
pubs.embargo.termsNo embargo
icr.researchteamSarcoma Clinical Trialsen_US
dc.contributor.icrauthorJudson, Ianen
dc.contributor.icrauthorFisher, Cyrilen


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