Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications.
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Date
2017-01Author
Szucs, Z
Thway, K
Fisher, C
Bulusu, R
Constantinidou, A
Benson, C
van der Graaf, WT
Jones, RL
Type
Journal Article
Metadata
Show full item recordAbstract
Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT and PDGFRA genes have been designated as 'wild-type' GISTs; however, they represent a heterogeneous group currently undergoing further subclassification. Primary and secondary resistance to imatinib poses a significant clinical challenge, therefore ongoing research is trying to evaluate mechanisms to overcome resistance. Thorough understanding of the prognostic and predictive relevance of different genetic subtypes of GIST can guide clinical decision-making both in the adjuvant and the metastatic setting. Further work is required to identify tailored therapies for specific subgroups of GISTs wild-type for KIT and PDGFRA mutations and to identify predictive factors of resistance to currently approved systemic therapies.
Collections
Subject
Animals
Humans
Gastrointestinal Stromal Tumors
Prognosis
Gene Duplication
Sequence Deletion
Genotype
Proto-Oncogene Proteins c-kit
Biomarkers, Tumor
Clinical Decision-Making
Research team
Clinical and Translational Sarcoma
Sarcoma Clinical Trials (R Jones)
Language
eng
License start date
2017-01
Citation
Future oncology (London, England), 2017, 13 (1), pp. 93 - 107