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dc.contributor.authorGonzalez Malagon, SGen_US
dc.contributor.authorLopez Muñoz, AMen_US
dc.contributor.authorDoro, Den_US
dc.contributor.authorBolger, TGen_US
dc.contributor.authorPoon, Een_US
dc.contributor.authorTucker, ERen_US
dc.contributor.authorAdel Al-Lami, Hen_US
dc.contributor.authorKrause, Men_US
dc.contributor.authorPhiel, CJen_US
dc.contributor.authorChesler, Len_US
dc.contributor.authorLiu, KJen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-03-16T10:01:25Z
dc.date.issued2018-03-19en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29555900en_US
dc.identifier10.1038/s41467-018-03512-5en_US
dc.identifier.citationNat Commun, 2018, 9 (1), pp. 1126 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1595
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/s41467-018-03512-5en_US
dc.description.abstractNeural crest migration is critical to its physiological function. Mechanisms controlling mammalian neural crest migration are comparatively unknown, due to difficulties accessing this cell population in vivo. Here we report requirements of glycogen synthase kinase 3 (GSK3) in regulating the neural crest in Xenopus and mouse models. We demonstrate that GSK3 is tyrosine phosphorylated (pY) in mouse neural crest cells and that loss of GSK3 leads to increased pFAK and misregulation of Rac1 and lamellipodin, key regulators of cell migration. Genetic reduction of GSK3 results in failure of migration. We find that pY-GSK3 phosphorylation depends on anaplastic lymphoma kinase (ALK), a protein associated with neuroblastoma. Consistent with this, neuroblastoma cells with increased ALK activity express high levels of pY-GSK3, and blockade of GSK3 or ALK can affect migration of these cells. Altogether, this work identifies a role for GSK3 in cell migration during neural crest development and cancer.en_US
dc.format.extent1126 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAnaplastic Lymphoma Kinaseen_US
dc.subjectAnimalsen_US
dc.subjectCell Line, Tumoren_US
dc.subjectCell Lineageen_US
dc.subjectCell Movementen_US
dc.subjectFemaleen_US
dc.subjectGlycogen Synthase Kinase 3en_US
dc.subjectGlycogen Synthase Kinase 3 betaen_US
dc.subjectHumansen_US
dc.subjectMiceen_US
dc.subjectMice, Knockouten_US
dc.subjectNeural Cresten_US
dc.subjectNeuroblastomaen_US
dc.subjectPhosphorylationen_US
dc.subjectPregnancyen_US
dc.subjectXenopus Proteinsen_US
dc.subjectXenopus laevisen_US
dc.titleGlycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-02-20en_US
rioxxterms.versionofrecord10.1038/s41467-018-03512-5en_US
rioxxterms.licenseref.startdate2018-03-19en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNat Communen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Paediatric Solid Tumour Biology and Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Paediatric Solid Tumour Biology and Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Paediatric Solid Tumour Biology and Therapeutics
pubs.publication-statusPublished onlineen_US
pubs.volume9en_US
pubs.embargo.termsNot knownen_US
icr.researchteamPaediatric Solid Tumour Biology and Therapeuticsen_US
dc.contributor.icrauthorChesler, Louisen_US
dc.contributor.icrauthorPoon, Evonen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/