Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit.
National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group
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The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.
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Proton beam therapy
external beam radiotherapy
ICR-CTSU Urology and Head and Neck Trials Team
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Clin Oncol (R Coll Radiol), 2018, 30 (5), pp. 280 - 284