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dc.contributor.authorViski, C
dc.contributor.authorKönig, C
dc.contributor.authorKijewska, M
dc.contributor.authorMogler, C
dc.contributor.authorIsacke, CM
dc.contributor.authorAugustin, HG
dc.date.accessioned2016-10-14T14:35:15Z
dc.date.issued2016-09
dc.identifier.citationCancer research, 2016, 76 (18), pp. 5313 - 5325
dc.identifier.issn0008-5472
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/163
dc.identifier.eissn1538-7445
dc.identifier.doi10.1158/0008-5472.can-16-0932
dc.description.abstractMetastasis is a multistep process that is critically dependent on the interaction of metastasizing tumor cells with cells in the local microenvironment. Within this tumor stroma, vessel-associated pericytes and myofibroblasts share a number of traits, including the upregulated expression of the transmembrane receptor endosialin (CD248). Comparative experiments in wild-type and endosialin-deficient mice revealed that stromal endosialin does not affect primary tumor growth but strongly promotes spontaneous metastasis. Mechanistically, endosialin-expressing pericytes in the primary tumor facilitate distant site metastasis by promoting tumor cell intravasation in a cell contact-dependent manner, resulting in elevated numbers of circulating tumor cells. Corresponding to these preclinical experiments, in independent cohorts of primary human breast cancers, upregulated endosialin expression significantly correlates with increased metastasis and poorer patient survival. Together, the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer. Cancer Res; 76(18); 5313-25. ©2016 AACR.
dc.formatPrint
dc.format.extent5313 - 5325
dc.languageeng
dc.language.isoeng
dc.subjectPericytes
dc.subjectAnimals
dc.subjectMice, Inbred BALB C
dc.subjectHumans
dc.subjectMice
dc.subjectMice, Nude
dc.subjectBreast Neoplasms
dc.subjectNeoplasms, Experimental
dc.subjectNeoplasm Invasiveness
dc.subjectNeoplasm Proteins
dc.subjectAntigens, CD
dc.subjectAntigens, Neoplasm
dc.subjectMicroscopy, Confocal
dc.subjectPolymerase Chain Reaction
dc.subjectFemale
dc.titleEndosialin-Expressing Pericytes Promote Metastatic Dissemination.
dc.typeJournal Article
dcterms.dateAccepted2016-07-18
rioxxterms.versionofrecord10.1158/0008-5472.can-16-0932
rioxxterms.licenseref.startdate2016-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer research
pubs.issue18
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Cell Biology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Cell Biology
pubs.publication-statusPublished
pubs.volume76en_US
pubs.embargo.termsNo embargo
icr.researchteamMolecular Cell Biologyen_US
dc.contributor.icrauthorViski, Carmenen
dc.contributor.icrauthorKijewska, Magdalenaen
dc.contributor.icrauthorIsacke, Clareen


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