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dc.contributor.authorViski, Cen_US
dc.contributor.authorKönig, Cen_US
dc.contributor.authorKijewska, Men_US
dc.contributor.authorMogler, Cen_US
dc.contributor.authorIsacke, CMen_US
dc.contributor.authorAugustin, HGen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2016-10-14T14:35:15Z
dc.date.issued2016-09-15en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27635044en_US
dc.identifier76/18/5313en_US
dc.identifier.citationCancer Res, 2016, 76 (18), pp. 5313 - 5325en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/163
dc.identifier.eissn1538-7445en_US
dc.identifier.doi10.1158/0008-5472.CAN-16-0932en_US
dc.description.abstractMetastasis is a multistep process that is critically dependent on the interaction of metastasizing tumor cells with cells in the local microenvironment. Within this tumor stroma, vessel-associated pericytes and myofibroblasts share a number of traits, including the upregulated expression of the transmembrane receptor endosialin (CD248). Comparative experiments in wild-type and endosialin-deficient mice revealed that stromal endosialin does not affect primary tumor growth but strongly promotes spontaneous metastasis. Mechanistically, endosialin-expressing pericytes in the primary tumor facilitate distant site metastasis by promoting tumor cell intravasation in a cell contact-dependent manner, resulting in elevated numbers of circulating tumor cells. Corresponding to these preclinical experiments, in independent cohorts of primary human breast cancers, upregulated endosialin expression significantly correlates with increased metastasis and poorer patient survival. Together, the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer. Cancer Res; 76(18); 5313-25. ©2016 AACR.en_US
dc.format.extent5313 - 5325en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectAnimalsen_US
dc.subjectAntigens, CDen_US
dc.subjectAntigens, Neoplasmen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMiceen_US
dc.subjectMice, Inbred BALB Cen_US
dc.subjectMice, Nudeen_US
dc.subjectMicroscopy, Confocalen_US
dc.subjectNeoplasm Invasivenessen_US
dc.subjectNeoplasm Proteinsen_US
dc.subjectNeoplasms, Experimentalen_US
dc.subjectPericytesen_US
dc.subjectPolymerase Chain Reactionen_US
dc.titleEndosialin-Expressing Pericytes Promote Metastatic Dissemination.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-07-18en_US
rioxxterms.versionofrecord10.1158/0008-5472.CAN-16-0932en_US
rioxxterms.licenseref.startdate2016-09-15en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer Resen_US
pubs.issue18en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Cell Biology
pubs.publication-statusPublisheden_US
pubs.volume76en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamMolecular Cell Biologyen_US
dc.contributor.icrauthorIsacke, Clareen_US
dc.contributor.icrauthorViski, Carmenen_US
dc.contributor.icrauthorKijewska, Magdalenaen_US


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