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dc.contributor.authorMüller, S
dc.contributor.authorAckloo, S
dc.contributor.authorArrowsmith, CH
dc.contributor.authorBauser, M
dc.contributor.authorBaryza, JL
dc.contributor.authorBlagg, J
dc.contributor.authorBöttcher, J
dc.contributor.authorBountra, C
dc.contributor.authorBrown, PJ
dc.contributor.authorBunnage, ME
dc.contributor.authorCarter, AJ
dc.contributor.authorDamerell, D
dc.contributor.authorDötsch, V
dc.contributor.authorDrewry, DH
dc.contributor.authorEdwards, AM
dc.contributor.authorEdwards, J
dc.contributor.authorElkins, JM
dc.contributor.authorFischer, C
dc.contributor.authorFrye, SV
dc.contributor.authorGollner, A
dc.contributor.authorGrimshaw, CE
dc.contributor.authorIJzerman, A
dc.contributor.authorHanke, T
dc.contributor.authorHartung, IV
dc.contributor.authorHitchcock, S
dc.contributor.authorHowe, T
dc.contributor.authorHughes, TV
dc.contributor.authorLaufer, S
dc.contributor.authorLi, VM
dc.contributor.authorLiras, S
dc.contributor.authorMarsden, BD
dc.contributor.authorMatsui, H
dc.contributor.authorMathias, J
dc.contributor.authorO'Hagan, RC
dc.contributor.authorOwen, DR
dc.contributor.authorPande, V
dc.contributor.authorRauh, D
dc.contributor.authorRosenberg, SH
dc.contributor.authorRoth, BL
dc.contributor.authorSchneider, NS
dc.contributor.authorScholten, C
dc.contributor.authorSingh Saikatendu, K
dc.contributor.authorSimeonov, A
dc.contributor.authorTakizawa, M
dc.contributor.authorTse, C
dc.contributor.authorThompson, PR
dc.contributor.authorTreiber, DK
dc.contributor.authorViana, AY
dc.contributor.authorWells, CI
dc.contributor.authorWillson, TM
dc.contributor.authorZuercher, WJ
dc.contributor.authorKnapp, S
dc.contributor.authorMueller-Fahrnow, A
dc.date.accessioned2018-05-08T09:50:20Z
dc.date.issued2018-04-20
dc.identifier.citationeLife, 2018, 7
dc.identifier.issn2050-084X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1669
dc.identifier.eissn2050-084X
dc.identifier.doi10.7554/elife.34311
dc.description.abstractPotent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (<ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de">https://openscienceprobes.sgc-frankfurt.de</ext-link><ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de/">/</ext-link>). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.
dc.formatElectronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectProteins
dc.subjectMolecular Probes
dc.subjectTechnology, Pharmaceutical
dc.subjectPharmacology
dc.titleDonated chemical probes for open science.
dc.typeJournal Article
dcterms.dateAccepted2018-03-29
rioxxterms.versionofrecord10.7554/elife.34311
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-04-20
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfeLife
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 1
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 1
pubs.publication-statusPublished
pubs.volume7
pubs.embargo.termsNo embargo
icr.researchteamMedicinal Chemistry 1en_US
dc.contributor.icrauthorBlagg, Julianen


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