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dc.contributor.authorMüller, Sen_US
dc.contributor.authorAckloo, Sen_US
dc.contributor.authorArrowsmith, CHen_US
dc.contributor.authorBauser, Men_US
dc.contributor.authorBaryza, JLen_US
dc.contributor.authorBlagg, Jen_US
dc.contributor.authorBöttcher, Jen_US
dc.contributor.authorBountra, Cen_US
dc.contributor.authorBrown, PJen_US
dc.contributor.authorBunnage, MEen_US
dc.contributor.authorCarter, AJen_US
dc.contributor.authorDamerell, Den_US
dc.contributor.authorDötsch, Ven_US
dc.contributor.authorDrewry, DHen_US
dc.contributor.authorEdwards, AMen_US
dc.contributor.authorEdwards, Jen_US
dc.contributor.authorElkins, JMen_US
dc.contributor.authorFischer, Cen_US
dc.contributor.authorFrye, SVen_US
dc.contributor.authorGollner, Aen_US
dc.contributor.authorGrimshaw, CEen_US
dc.contributor.authorIJzerman, Aen_US
dc.contributor.authorHanke, Ten_US
dc.contributor.authorHartung, IVen_US
dc.contributor.authorHitchcock, Sen_US
dc.contributor.authorHowe, Ten_US
dc.contributor.authorHughes, TVen_US
dc.contributor.authorLaufer, Sen_US
dc.contributor.authorLi, VMen_US
dc.contributor.authorLiras, Sen_US
dc.contributor.authorMarsden, BDen_US
dc.contributor.authorMatsui, Hen_US
dc.contributor.authorMathias, Jen_US
dc.contributor.authorO'Hagan, RCen_US
dc.contributor.authorOwen, DRen_US
dc.contributor.authorPande, Ven_US
dc.contributor.authorRauh, Den_US
dc.contributor.authorRosenberg, SHen_US
dc.contributor.authorRoth, BLen_US
dc.contributor.authorSchneider, NSen_US
dc.contributor.authorScholten, Cen_US
dc.contributor.authorSingh Saikatendu, Ken_US
dc.contributor.authorSimeonov, Aen_US
dc.contributor.authorTakizawa, Men_US
dc.contributor.authorTse, Cen_US
dc.contributor.authorThompson, PRen_US
dc.contributor.authorTreiber, DKen_US
dc.contributor.authorViana, AYen_US
dc.contributor.authorWells, CIen_US
dc.contributor.authorWillson, TMen_US
dc.contributor.authorZuercher, WJen_US
dc.contributor.authorKnapp, Sen_US
dc.contributor.authorMueller-Fahrnow, Aen_US
dc.date.accessioned2018-05-08T09:50:20Z
dc.date.issued2018-04-20en_US
dc.identifier.citationeLife, 2018, 7en_US
dc.identifier.issn2050-084Xen_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1669
dc.identifier.eissn2050-084Xen_US
dc.identifier.doi10.7554/elife.34311en_US
dc.description.abstractPotent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (<ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de">https://openscienceprobes.sgc-frankfurt.de</ext-link><ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de/">/</ext-link>). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.en_US
dc.formatElectronicen_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectProteinsen_US
dc.subjectMolecular Probesen_US
dc.subjectTechnology, Pharmaceuticalen_US
dc.subjectPharmacologyen_US
dc.titleDonated chemical probes for open science.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-03-29en_US
rioxxterms.versionofrecord10.7554/elife.34311en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2018-04-20en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfeLifeen_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 1
pubs.publication-statusPublisheden_US
pubs.volume7en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamMedicinal Chemistry 1en_US
dc.contributor.icrauthorBlagg, Julianen_US


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