Donated chemical probes for open science.
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Date
2018-04-20ICR Author
Author
Müller, S
Ackloo, S
Arrowsmith, CH
Bauser, M
Baryza, JL
Blagg, J
Böttcher, J
Bountra, C
Brown, PJ
Bunnage, ME
Carter, AJ
Damerell, D
Dötsch, V
Drewry, DH
Edwards, AM
Edwards, J
Elkins, JM
Fischer, C
Frye, SV
Gollner, A
Grimshaw, CE
IJzerman, A
Hanke, T
Hartung, IV
Hitchcock, S
Howe, T
Hughes, TV
Laufer, S
Li, VM
Liras, S
Marsden, BD
Matsui, H
Mathias, J
O'Hagan, RC
Owen, DR
Pande, V
Rauh, D
Rosenberg, SH
Roth, BL
Schneider, NS
Scholten, C
Singh Saikatendu, K
Simeonov, A
Takizawa, M
Tse, C
Thompson, PR
Treiber, DK
Viana, AY
Wells, CI
Willson, TM
Zuercher, WJ
Knapp, S
Mueller-Fahrnow, A
Type
Journal Article
Metadata
Show full item recordAbstract
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (<ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de">https://openscienceprobes.sgc-frankfurt.de</ext-link><ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de/">/</ext-link>). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.
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Subject
Proteins
Molecular Probes
Technology, Pharmaceutical
Pharmacology
Research team
Medicinal Chemistry 1
Language
eng
Date accepted
2018-03-29
License start date
2018-04-20
Citation
eLife, 2018, 7