Women's Free-text Comments on their Quality of Life: An Exploratory Analysis from the UK Standardisation of Breast Radiotherapy (START) Trials for Early Breast Cancer.
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Date
2018-07-01Author
Mills, J
Haviland, JS
Moynihan, C
Bliss, JM
Hopwood, P
START Trial Management Group,
Type
Journal Article
Metadata
Show full item recordAbstract
AIMS: Exploratory analysis of patients' unsolicited written comments in the first 2 years of the Standardisation of Breast Radiotherapy (START) trial quality of life study highlighted a potential effect of non-treatment-related problems on the ratings and interpretation of patient self-reported questionnaires. At 5 years of follow-up all eligible subjects were invited to write comments to further explore these findings. MATERIALS AND METHODS: Using inductive qualitative methods informed by the exploratory analysis, comments were allocated to relevant themes. Key patient-reported outcome measures (PROMs), clinical and demographic factors were collated for patients who did and did not comment at 5 years and comparisons between the groups explored. RESULTS: Of 2208 women completing baseline PROMs, 482 proffered comments from 0 to 24 months, forming nine distinct themes, including chronic conditions, life events and psychosocial concerns. At 5 years, 1041/1727 (60.3%) women contributed comments, of whom 500 randomly selected participants formed the sample for analysis. Findings revealed comorbidity, impaired physical functioning and psychosocial problems as key themes, with prevalent adverse effects from local and systemic treatments. Eight new themes emerged at 5 years, including ageing, concerns about future cancer and positive aspects of care. Women commenting were better educated, slightly older and more likely to have had chemotherapy compared with non-commenters. They had significantly worse PROM scores for global health and key quality of life domains relevant to the difficulties they revealed. CONCLUSIONS: Difficult personal circumstances and other health concerns affected many women's PROM ratings at 5 years of follow-up, in addition to ongoing cancer treatment effects. Greater attention to multiple sources of distress and adversity could facilitate personalised care and aid interpretation of PROMs.
Collections
Subject
START Trial Management Group
Humans
Breast Neoplasms
Quality of Life
Adult
Aged
Middle Aged
Female
Randomized Controlled Trials as Topic
Surveys and Questionnaires
United Kingdom
Patient Reported Outcome Measures
Research team
Clinical Trials & Statistics Unit
Language
eng
Date accepted
2018-03-06
License start date
2018-07
Citation
Clinical oncology (Royal College of Radiologists (Great Britain)), 2018, 30 (7), pp. 433 - 441
Publisher
ELSEVIER SCIENCE LONDON