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dc.contributor.authorHekman, MCHen_US
dc.contributor.authorRijpkema, Men_US
dc.contributor.authorAarntzen, EHen_US
dc.contributor.authorMulder, SFen_US
dc.contributor.authorLangenhuijsen, JFen_US
dc.contributor.authorOosterwijk, Een_US
dc.contributor.authorBoerman, OCen_US
dc.contributor.authorOyen, WJGen_US
dc.contributor.authorMulders, PFAen_US
dc.date.accessioned2018-05-22T09:11:46Z
dc.date.issued2018-09en_US
dc.identifier.citationEuropean urology, 2018, 74 (3), pp. 257 - 260en_US
dc.identifier.issn0302-2838en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1681
dc.identifier.eissn1873-7560en_US
dc.identifier.doi10.1016/j.eururo.2018.04.026en_US
dc.description.abstractBased on the high expression of carbonic anhydrase IX (CAIX) in 95% of clear cell renal cell carcinoma (ccRCC), the anti-CAIX monoclonal antibody girentuximab can be used for the detection of ccRCC. This clinical study explores the value of <sup>89</sup>Zr-labeled girentuximab positron emission tomography/computed tomography (PET/CT) imaging in diagnostic challenges regarding ccRCC. PET/CT imaging was performed 4 or 5 d after injection of <sup>89</sup>Zr-girentuximab in patients with a primary renal mass (n=16) or a history of ccRCC (n=14). Scans were used for decision making (surgery/active surveillance) in case of indistinct renal masses. All resected PET-positive primary lesions proved to be ccRCC, while no lesion progression was seen in PET-negative masses. In patients suspected of recurrent/metastatic ccRCC, PET/CT with <sup>89</sup>Zr-girentuximab was useful to confirm or exclude ccRCC, evaluate the extent of the disease, and differentiate from other cancers. In this group, <sup>89</sup>Zr-girentuximab PET/CT resulted in a major change in clinical management in five patients (36%), while in three patients (21%) repeat biopsies could be avoided. We conclude that <sup>89</sup>Zr-girentuximab PET/CT is a valuable diagnostic tool that can guide clinical decision making in case of diagnostic dilemmas concerning ccRCC suspicion.<h4>Patient summary</h4>Positron emission tomography/computed tomography imaging with <sup>89</sup>Zr-girentuximab can be a valuable diagnostic tool to identify clear cell renal cell carcinoma.en_US
dc.formatPrint-Electronicen_US
dc.format.extent257 - 260en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.subjectHumansen_US
dc.subjectCarcinoma, Renal Cellen_US
dc.subjectKidney Neoplasmsen_US
dc.subjectAntibodies, Monoclonalen_US
dc.subjectAntigens, Neoplasmen_US
dc.subjectRadiopharmaceuticalsen_US
dc.subjectDiagnosis, Differentialen_US
dc.subjectNephrectomyen_US
dc.subjectPredictive Value of Testsen_US
dc.subjectDecision Support Techniquesen_US
dc.subjectPatient Selectionen_US
dc.subjectWatchful Waitingen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectClinical Decision-Makingen_US
dc.subjectCarbonic Anhydrase IXen_US
dc.subjectPositron Emission Tomography Computed Tomographyen_US
dc.titlePositron Emission Tomography/Computed Tomography with <sup>89</sup>Zr-girentuximab Can Aid in Diagnostic Dilemmas of Clear Cell Renal Cell Carcinoma Suspicion.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-04-19en_US
rioxxterms.versionofrecord10.1016/j.eururo.2018.04.026en_US
rioxxterms.licenseref.startdate2018-09en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfEuropean urologyen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.publication-statusPublisheden_US
pubs.volume74en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTranslational Molecular Imagingen_US
dc.contributor.icrauthorOyen, Willemen_US


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