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dc.contributor.authorKouijzer, IJEen_US
dc.contributor.authorBerrevoets, MAHen_US
dc.contributor.authorAarntzen, EHJGen_US
dc.contributor.authorde Vries, Jen_US
dc.contributor.authorvan Dijk, APJen_US
dc.contributor.authorOyen, WJGen_US
dc.contributor.authorde Geus-Oei, L-Fen_US
dc.contributor.authorBleeker-Rovers, CPen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-06-11T08:21:17Z
dc.date.issued2018-08en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29762262en_US
dc.identifier.citationNucl Med Commun, 2018, 39 (8), pp. 747 - 752en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1780
dc.identifier.eissn1473-5628en_US
dc.identifier.doi10.1097/MNM.0000000000000864en_US
dc.description.abstractOBJECTIVE: The aim of the study was to investigate the value of F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). PATIENTS AND METHODS: All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and F-FDG-PET/CT were performed within 14 days. F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. RESULTS: A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal F-FDG-PET/CT result. CONCLUSION: A negative F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform F-FDG-PET/CT in all patients with suspected NVE.en_US
dc.format.extent747 - 752en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectCohort Studiesen_US
dc.subjectEndocarditisen_US
dc.subjectFemaleen_US
dc.subjectFluorodeoxyglucose F18en_US
dc.subjectHeart Valvesen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPositron Emission Tomography Computed Tomographyen_US
dc.subjectRetrospective Studiesen_US
dc.title18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1097/MNM.0000000000000864en_US
rioxxterms.licenseref.startdate2018-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNucl Med Communen_US
pubs.issue8en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.publication-statusPublisheden_US
pubs.volume39en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTranslational Molecular Imagingen_US
dc.contributor.icrauthorOyen, Willemen_US


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