Show simple item record

dc.contributor.authorKouijzer, IJE
dc.contributor.authorBerrevoets, MAH
dc.contributor.authorAarntzen, EHJG
dc.contributor.authorde Vries, J
dc.contributor.authorvan Dijk, APJ
dc.contributor.authorOyen, WJG
dc.contributor.authorde Geus-Oei, L-F
dc.contributor.authorBleeker-Rovers, CP
dc.date.accessioned2018-06-11T08:21:17Z
dc.date.issued2018-08
dc.identifier.citationNuclear medicine communications, 2018, 39 (8), pp. 747 - 752
dc.identifier.issn0143-3636
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1780
dc.identifier.eissn1473-5628
dc.identifier.doi10.1097/mnm.0000000000000864
dc.description.abstractOBJECTIVE:The aim of the study was to investigate the value of F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). PATIENTS AND METHODS:All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and F-FDG-PET/CT were performed within 14 days. F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. RESULTS:A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal F-FDG-PET/CT result. CONCLUSION:A negative F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform F-FDG-PET/CT in all patients with suspected NVE.
dc.formatPrint
dc.format.extent747 - 752
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectHeart Valves
dc.subjectHumans
dc.subjectEndocarditis
dc.subjectFluorodeoxyglucose F18
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectPositron Emission Tomography Computed Tomography
dc.title18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis.
dc.typeJournal Article
rioxxterms.versionofrecord10.1097/mnm.0000000000000864
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2018-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNuclear medicine communications
pubs.issue8
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.publication-statusPublished
pubs.volume39
pubs.embargo.termsNot known
icr.researchteamTranslational Molecular Imagingen_US
dc.contributor.icrauthorOyen, Willem


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record