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dc.contributor.authorHahne, JCen_US
dc.contributor.authorValeri, Nen_US
dc.date.accessioned2018-06-11T08:26:51Z
dc.date.accessioned2018-06-11T09:04:26Z
dc.date.issued2018-01en_US
dc.identifier.citationFrontiers in oncology, 2018, 8 pp. 226 - ?en_US
dc.identifier.issn2234-943Xen_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1785
dc.identifier.eissn2234-943Xen_US
dc.identifier.doi10.3389/fonc.2018.00226en_US
dc.description.abstractNon-coding RNAs are important regulators of gene expression and transcription. It is well established that impaired non-coding RNA expression especially the one of long non-coding RNAs and microRNAs is involved in a number of pathological conditions including cancer. Non-coding RNAs are responsible for the development of resistance to anticancer treatments as they regulate drug resistance-related genes, affect intracellular drug concentrations, induce alternative signaling pathways, alter drug efficiency <i>via</i> blocking cell cycle regulation, and DNA damage response. Furthermore, they can prevent therapeutic-induced cell death and promote epithelial-mesenchymal transition (EMT) and elicit non-cell autonomous mechanisms of resistance. In this review, we summarize the role of non-coding RNAs for different mechanisms resulting in drug resistance (e.g., drug transport, drug metabolism, cell cycle regulation, regulation of apoptotic pathways, cancer stem cells, and EMT) in the context of gastrointestinal cancers.en_US
dc.formatElectronic-eCollectionen_US
dc.format.extent226 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.relation.replaceshttps://repository.icr.ac.uk/handle/internal/1781
dc.relation.replacesinternal/1781
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleNon-Coding RNAs and Resistance to Anticancer Drugs in Gastrointestinal Tumors.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-05-31en_US
rioxxterms.versionofrecord10.3389/fonc.2018.00226en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2018-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfFrontiers in oncologyen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.publication-statusPublisheden_US
pubs.volume8en_US
pubs.embargo.termsNot knownen_US
icr.researchteamGastrointestinal Cancer Biology and Genomicsen_US
dc.contributor.icrauthorHahne, Jensen_US
dc.contributor.icrauthorValeri, Nicolaen_US


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