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dc.contributor.authorJerome, NP
dc.contributor.authorBoult, JKR
dc.contributor.authorOrton, MR
dc.contributor.authord'Arcy, J
dc.contributor.authorCollins, DJ
dc.contributor.authorLeach, MO
dc.contributor.authorKoh, D-M
dc.contributor.authorRobinson, SP
dc.date.accessioned2016-10-31T14:08:43Z
dc.date.issued2016-10-03
dc.identifier.citationBMC nephrology, 2016, 17 (1), pp. 142 - ?
dc.identifier.issn1471-2369
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/195
dc.identifier.eissn1471-2369
dc.identifier.doi10.1186/s12882-016-0356-x
dc.description.abstractBACKGROUND: To investigate the combined use of intravoxel incoherent motion (IVIM) diffusion-weighted (DW) and blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) to assess rat renal function using a 1.5T clinical platform. METHODS: Multiple b-value DW and BOLD MR images were acquired from adult rats using a parallel clinical coil arrangement, enabling quantitation of the apparent diffusion coefficient (ADC), IVIM-derived diffusion coefficient (D), pseudodiffusion coefficient (D*) and perfusion fraction (f), and the transverse relaxation time T2*, for whole kidney, renal cortex, and medulla. Following the acquisition of two baseline datasets to assess measurement repeatability, images were acquired following i.v. administration of hydralazine, furosemide, or angiotensin II for up to 40 min. RESULTS: Excellent repeatability (CoV <10 %) was observed for ADC, D, f and T2* measured over the whole kidney. Hydralazine induced a marked and significant (p < 0.05) reduction in whole kidney ADC, D, and T2*, and a significant (p < 0.05) increase in D* and f. Furosemide significantly (p < 0.05) increased whole kidney ADC, D, and T2*. A more variable response to angiotensin II was determined, with a significant (p < 0.05) increase in medulla D* and significant (p < 0.05) reduction in whole kidney T2* established. CONCLUSIONS: Multiparametric MRI, incorporating quantitation of IVIM DWI and BOLD biomarkers and performed on a clinical platform, can be used to monitor the acute effects of vascular and tubular modulating drugs on rat kidney function in vivo. Clinical adoption of such functional imaging biomarkers can potentially inform on treatment effects in patients with renal dysfunction.
dc.formatElectronic
dc.format.extent142 - ?
dc.languageeng
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectKidney
dc.subjectAnimals
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectOxygen
dc.subjectFurosemide
dc.subjectHydralazine
dc.subjectAngiotensin II
dc.subjectAntihypertensive Agents
dc.subjectVasoconstrictor Agents
dc.subjectDiuretics
dc.subjectMagnetic Resonance Imaging
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectReproducibility of Results
dc.subjectDiffusion
dc.subjectFemale
dc.titleModulation of renal oxygenation and perfusion in rat kidney monitored by quantitative diffusion and blood oxygen level dependent magnetic resonance imaging on a clinical 1.5T platform.
dc.typeJournal Article
dcterms.dateAccepted2016-09-26
rioxxterms.versionofrecord10.1186/s12882-016-0356-x
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-10-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBMC nephrology
pubs.issue1
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume17
pubs.embargo.termsNo embargo
icr.researchteamMagnetic Resonance
icr.researchteamPre-Clinical MRI
dc.contributor.icrauthorBoult, Jessica
dc.contributor.icrauthorCollins, David
dc.contributor.icrauthorLeach, Martin
dc.contributor.icrauthorRobinson, Simon


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