dc.date.accessioned | 2018-07-10T10:29:31Z | |
dc.date.issued | 2012-03-01 | |
dc.identifier | http://www.plosone.org/article/info%3Adoi/10.1371/journal.pone.0033792 | |
dc.identifier.citation | PLOS ONE, 2012, 7 (3) | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2011 | |
dc.description.abstract | Background: Sheep (Ovis aries) were domesticated in the Fertile Crescent region about 9,000-8,000 years ago. Currently, few mitochondrial (mt) DNA studies are available on archaeological sheep. In particular, no data on archaeological European sheep are available. Methodology/Principal Findings: Here we describe the first portion of mtDNA sequence of a Copper Age European sheep. DNA was extracted from hair shafts which were part of the clothes of the so-called Tyrolean Iceman or Otzi (5,350 -5,100 years before present). Mitochondrial DNA (a total of 2,429 base pairs, encompassing a portion of the control region, tRNA(Phe), a portion of the 12S rRNA gene, and the whole cytochrome B gene) was sequenced using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products. We have compared the sequence with the corresponding sequence of 334 extant lineages. Conclusions/Significance: A phylogenetic network based on a new cladistic notation for the mitochondrial diversity of domestic sheep shows that the Otzi's sheep falls within haplogroup B, thus demonstrating that sheep belonging to this haplogroup were already present in the Alps more than 5,000 years ago. On the other hand, the lineage of the Otzi's sheep is defined by two transitions (16147, and 16440) which, assembled together, define a motif that has not yet been identified in modern sheep populations. | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | domestic sheep hair shafts miscoding lesions ancient dna genome sequence networks lineages events europe | |
dc.title | Phylogenetic Position of a Copper Age Sheep (Ovis aries) Mitochondrial DNA | |
dc.type | Journal Article | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2012-03 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | PLOS ONE | |
pubs.issue | 3 | |
pubs.notes | ISI Document Delivery No.: 942MA Times Cited: 0 Cited Reference Count: 44 Olivieri, Cristina Ermini, Luca Rizzi, Ermanno Corti, Giorgio Luciani, Stefania Marota, Isolina De Bellis, Gianluca Rollo, Franco Ministero per l'Istruzione, l'Universita e la Ricerca (MIUR) This study was supported by a Ministero per l'Istruzione, l'Universita e la Ricerca (MIUR) research project "Tecniche Biomolecolari in Archeo-Antropologia per una nuova storia delle malattie". The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Public library science San francisco | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia | |
pubs.volume | 7 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Biology of Childhood Leukaemia | |
dc.contributor.icrauthor | Ermini, Luca | |