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dc.contributor.authorHeskamp, S
dc.contributor.authorHeijmen, L
dc.contributor.authorGerrits, D
dc.contributor.authorMolkenboer-Kuenen, JDM
dc.contributor.authorTer Voert, EGW
dc.contributor.authorHeinzmann, K
dc.contributor.authorHoness, DJ
dc.contributor.authorSmith, DM
dc.contributor.authorGriffiths, JR
dc.contributor.authorDoblas, S
dc.contributor.authorSinkus, R
dc.contributor.authorLaverman, P
dc.contributor.authorOyen, WJG
dc.contributor.authorHeerschap, A
dc.contributor.authorBoerman, OC
dc.coverage.spatialUnited States
dc.date.accessioned2016-11-14T16:49:27Z
dc.date.issued2017-08
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/27798786
dc.identifier10.1007/s11307-016-1021-2
dc.identifier.citationMol Imaging Biol, 2017, 19 (4), pp. 540 - 549
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/205
dc.identifier.eissn1860-2002
dc.identifier.doi10.1007/s11307-016-1021-2
dc.description.abstractPURPOSE: The aim of the study was to investigate the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) and 3'-dexoy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) as early biomarkers of treatment response of 5-fluorouracil (5-FU) in a syngeneic rat model of colorectal cancer liver metastases. PROCEDURES: Wag/Rij rats with intrahepatic syngeneic CC531 tumors were treated with 5-FU (15, 30, or 60 mg/kg in weekly intervals). Before treatment and at days 1, 3, 7, and 14 after treatment rats underwent DW-MRI and [(18)F]FLT PET. Tumors were analyzed immunohistochemically for Ki67, TK1, and ENT1 expression. RESULTS: 5-FU inhibited the growth of CC531 tumors in a dose-dependent manner. Immunohistochemical analysis did not show significant changes in Ki67, TK1, and ENT1 expression. However, [(18)F]FLT SUVmean and SUVmax were significantly increased at days 4 and 7 after treatment with 5-FU (60 mg/kg) and returned to baseline at day 14 (SUVmax at days -1, 4, 7, and 14 was 1.1 ± 0.1, 2.3 ± 0.5, 2.3 ± 0.6, and 1.5 ± 0.4, respectively). No changes in [(18)F]FLT uptake were observed in the nontreated animals. Furthermore, the apparent diffusion coefficient (ADCmean) did not change in 5-FU-treated rats compared to untreated rats. CONCLUSION: This study suggests that 5-FU treatment induces a flare in [(18)F]FLT uptake of responsive CC531 tumors in the liver, while the ADCmean did not change significantly. Future studies in larger groups are warranted to further investigate whether [(18)F]FLT PET can discriminate between disease progression and treatment response.
dc.format.extent540 - 549
dc.languageeng
dc.language.isoeng
dc.relation.isreplacedbyinternal/739
dc.relation.isreplacedbyhttps://repository.icr.ac.uk/handle/internal/739
dc.subject5-Fluorouracil
dc.subjectColorectal cancer
dc.subjectDiffusion-weighted MRI
dc.subjectResponse monitoring
dc.subject[18F]FLT PET
dc.titleResponse Monitoring with [(18)F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.
dc.typeJournal Article
dcterms.dateAccepted2016-10-06
rioxxterms.versionofrecord10.1007/s11307-016-1021-2
rioxxterms.licenseref.startdate2017-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMol Imaging Biol
pubs.declined2016-11-14T16:48:30.558+0000
pubs.deleted2016-11-14T16:48:30.558+0000
pubs.issue4
pubs.merge-tointernal/739
pubs.merge-tohttps://repository.icr.ac.uk/handle/internal/739
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.publication-statusPublished
pubs.volume19
pubs.embargo.termsNot known
icr.researchteamTranslational Molecular Imagingen_US
dc.contributor.icrauthorOyen, Willemen


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