dc.date.accessioned | 2018-07-16T14:49:28Z | |
dc.date.issued | 2015-08-01 | |
dc.identifier | http://publications.icr.ac.uk/14355/ | |
dc.identifier.citation | PLOS ONE, 2015, 10 (8) | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2076 | |
dc.description.abstract | Generalised Anxiety Disorder (GAD) is a common anxiety-related diagnosis, affecting approximately 5% of the adult population. One characteristic of GAD is a high degree of anxiety sensitivity (AS), a personality trait which describes the fear of arousal-related sensations. Here we present a genome-wide association study of AS using a cohort of 730 MZ and DZ female twins. The GWAS showed a significant association for a variant within the RBFOX1 gene. A heritability analysis of the same cohort also confirmed a significant genetic component with h2 of 0.42. Additionally, a subset of the cohort (25 MZ twins discordant for AS) was studied for evidence of differential expression using RNA-seq data. Significant differential expression of two exons with the ITM2B gene within the discordant MZ subset was observed, a finding that was replicated in an independent cohort. While previous research has shown that anxiety has a high comorbidity with a variety of psychiatric and neurodegenerative disorders, our analysis suggests a novel etiology specific to AS. | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | GABA(A) RECEPTOR FUNCTION PSYCHOMETRIC PROPERTIES SENSITIVITY INDEX PERIPHERAL-BLOOD HERITABILITY DEPRESSION FEARFULNESS MODULATION INVENTORY SYMPTOMS Multidisciplinary Sciences | |
dc.title | Generalised Anxiety Disorder - A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression | |
dc.type | Journal Article | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2015-08 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | PLOS ONE | |
pubs.issue | 8 | |
pubs.notes | ISI Document Delivery No.: CO9KD Times Cited: 0 Cited Reference Count: 71 Davies, Matthew N. Verdi, Serena Burri, Andrea Trzaskowski, Maciej Lee, Minyoung Hettema, John M. Jansen, Rick Boomsma, Dorret I. Spector, Tim D. EU FP7 grant EuroBATS [259749]; National Institute for Health Research (NIHR) Clinical Research Facility at Guy's & St Thomas' NHS Foundation Trust; NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust; King's College London; Swiss National Science Foundation The study is supported by the EU FP7 grant EuroBATS (No. 259749) and also receives support from the National Institute for Health Research (NIHR) Clinical Research Facility at Guy's & St Thomas' NHS Foundation Trust and NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. Tim Spector is holder of an ERC Advanced Principal Investigator award. Andrea Burri holds an Ambizione personal career fellowship from the Swiss National Science Foundation. SNP Genotyping was performed by The Wellcome Trust Sanger Institute and National Eye Institute via NIH/CIDR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 0 PUBLIC LIBRARY SCIENCE SAN FRANCISCO PLOS ONE | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics | |
pubs.volume | 10 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Translational Oncogenomics | |
dc.contributor.icrauthor | Davies, Matthew | |