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dc.contributor.authorReinhart, AM
dc.contributor.authorFast, MF
dc.contributor.authorZiegenhein, P
dc.contributor.authorNill, S
dc.contributor.authorOelfke, U
dc.date.accessioned2016-11-18T16:05:31Z
dc.date.issued2017-01
dc.identifier.citationThe British journal of radiology, 2017, 90 (1069), pp. 20160426 - ?
dc.identifier.issn0007-1285
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/210
dc.identifier.eissn1748-880X
dc.identifier.doi10.1259/bjr.20160426
dc.description.abstractObjective Mimicking state-of-the-art patient radiotherapy with high-precision irradiators for small animals is expected to advance the understanding of dose-effect relationships and radiobiology in general. We work on the implementation of intensity-modulated radiotherapy-like irradiation schemes for small animals. As a first step, we present a fast analytical dose calculation algorithm for keV photon beams.Methods We follow a superposition-convolution approach adapted to kV X-rays, based on previous work for microbeam therapy. We assume local energy deposition at the photon interaction point due to the short electron ranges in tissue. This allows us to separate the dose calculation into locally absorbed primary dose and the scatter contribution, calculated in a point kernel approach. We validate our dose model against Geant4 Monte Carlo (MC) simulations and compare the results to Muriplan (XStrahl Ltd, Camberley, UK).Results For field sizes of (1 mm) 2 to (1 cm) 2 in water, the depth dose curves show a mean disagreement of 1.7% to MC simulations, with the largest deviations in the entrance region (4%) and at large depths (5% at 7 cm). Larger discrepancies are observed at water-to-bone boundaries, in bone and at the beam edges in slab phantoms and a mouse brain. Calculation times are in the order of 5 s for a single beam.Conclusion The algorithm shows good agreement with MC simulations in an initial validation. It has the potential to become an alternative to full MC dose calculation. Advances in knowledge: The presented algorithm demonstrates the potential of kernel-based dose calculation for kV photon beams. It will be valuable in intensity-modulated radiotherapy and inverse treatment planning for high precision small-animal radiotherapy.
dc.formatPrint-Electronic
dc.format.extent20160426 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.subjectHumans
dc.subjectRadiotherapy Dosage
dc.subjectRadiotherapy Planning, Computer-Assisted
dc.subjectMonte Carlo Method
dc.subjectPhantoms, Imaging
dc.subjectAlgorithms
dc.subjectPhotons
dc.subjectRadiotherapy, Intensity-Modulated
dc.titleA kernel-based dose calculation algorithm for kV photon beams with explicit handling of energy and material dependencies.
dc.typeJournal Article
dcterms.dateAccepted2016-10-25
rioxxterms.versionofrecord10.1259/bjr.20160426
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0
rioxxterms.licenseref.startdate2017-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfThe British journal of radiology
pubs.issue1069
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublished
pubs.volume90
pubs.embargo.termsNo embargo
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorReinhart, Annaen
dc.contributor.icrauthorOelfke, Uween
dc.contributor.icrauthorNill, Simeonen


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