Noncoding RNAs as novel biomarkers in pancreatic cancer: what do we know?
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Date
2017-02-01Author
Previdi, MC
Carotenuto, P
Zito, D
Pandolfo, R
Braconi, C
Type
Journal Article
Metadata
Show full item recordAbstract
Pancreatic cancer is an aggressive cancer of the digestive system, which is becoming a serious health problem worldwide. Overall survival for patients with pancreatic cancer is poor, mainly due to a lack of biomarkers to enable early diagnosis and a lack of prognostic markers that can inform decision-making, facilitating personalized treatment and an optimal clinical outcome. ncRNAs play an important role in pancreatic carcinogenesis. Here we review the literature on the role of ncRNAs as biomarkers in pancreatic cancer. We focus on the significance of ncRNAs as markers for early diagnosis, as prognostic biomarkers able to inform clinical management and as targets for novel therapeutics for patients with pancreatic cancer.
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Subject
Humans
Adenocarcinoma
Pancreatic Neoplasms
MicroRNAs
RNA, Messenger
RNA, Untranslated
Prognosis
Gene Expression Regulation, Neoplastic
Genetic Therapy
RNA, Long Noncoding
Biomarkers, Tumor
Research team
Signal Transduction & Molecular Pharmacology
Language
eng
License start date
2017-02
Citation
Future oncology (London, England), 2017, 13 (5), pp. 443 - 453
Publisher
FUTURE MEDICINE LTD