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dc.contributor.authorTan, MPen_US
dc.contributor.authorAttard, Gen_US
dc.contributor.authorHuddart, RAen_US
dc.coverage.spatialSwitzerlanden_US
dc.date.accessioned2018-09-12T13:08:43Z
dc.date.issued2018-08-29en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30158468en_US
dc.identifierijms19092568en_US
dc.identifier.citationInt J Mol Sci, 2018, 19 (9)en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2665
dc.identifier.eissn1422-0067en_US
dc.identifier.doi10.3390/ijms19092568en_US
dc.description.abstractCirculating tumour DNA (ctDNA) is an attractive tool in cancer research, offering many advantages over tissue samples obtained using traditional biopsy methods. There has been increasing interest in its application to muscle-invasive bladder cancer (MIBC), which is recognised to be a heterogeneous disease with overall poor prognosis. Using a range of platforms, studies have shown that ctDNA is detectable in MIBC and may be a useful biomarker in monitoring disease status and guiding treatment decisions in MIBC patients. Currently, with no such predictive or prognostic biomarkers in clinical practice to guide treatment strategy, there is a real unmet need for a personalised medicine approach in MIBC, and ctDNA offers an exciting avenue through which to pursue this goal. In this article, we present an overview of work to date on ctDNA in MIBC, and discuss the inherent challenges present as well as the potential future clinical applications.en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectbiomarkeren_US
dc.subjectcirculating tumour DNA (ctDNA)en_US
dc.subjectmuscle-invasive bladder cancer (MIBC)en_US
dc.subjectAnimalsen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectCirculating Tumor DNAen_US
dc.subjectHumansen_US
dc.subjectUrinary Bladder Neoplasmsen_US
dc.titleCirculating Tumour DNA in Muscle-Invasive Bladder Cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-08-27en_US
rioxxterms.versionofrecord10.3390/ijms19092568en_US
rioxxterms.licenseref.startdate2018-08-29en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfInt J Mol Scien_US
pubs.issue9en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Horwich)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.publication-statusPublished onlineen_US
pubs.volume19en_US
pubs.embargo.termsNot knownen_US
icr.researchteamClinical Academic Radiotherapy (Horwich)en_US
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
dc.contributor.icrauthorHuddart, Roberten_US
dc.contributor.icrauthorTan, Melissaen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/