Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.
Date
2016-05-26ICR Author
Author
Cheeseman, MD
Westwood, IM
Barbeau, O
Rowlands, M
Dobson, S
Jones, AM
Jeganathan, F
Burke, R
Kadi, N
Workman, P
Collins, I
van Montfort, RLM
Jones, K
Type
Journal Article
Metadata
Show full item recordAbstract
HSP70 is a molecular chaperone and a key component of the heat-shock response. Because of its proposed importance in oncology, this protein has become a popular target for drug discovery, efforts which have as yet brought little success. This study demonstrates that adenosine-derived HSP70 inhibitors potentially bind to the protein with a novel mechanism of action, the stabilization by desolvation of an intramolecular salt-bridge which induces a conformational change in the protein, leading to high affinity ligands. We also demonstrate that through the application of this mechanism, adenosine-derived HSP70 inhibitors can be optimized in a rational manner.
Collections
Subject
Humans
Adenosine
Crystallography, X-Ray
Molecular Conformation
Structure-Activity Relationship
Dose-Response Relationship, Drug
Models, Molecular
HSP70 Heat-Shock Proteins
Research team
Medicinal Chemistry 2
Medicinal Chemistry 3
Hit Discovery & Structural Design
Language
eng
Date accepted
2016-04-26
License start date
2016-05-11
Citation
Journal of medicinal chemistry, 2016, 59 (10), pp. 4625 - 4636
Publisher
AMER CHEMICAL SOC