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dc.contributor.authorMoquet, J
dc.contributor.authorHigueras, M
dc.contributor.authorDonovan, E
dc.contributor.authorBoyle, S
dc.contributor.authorBarnard, S
dc.contributor.authorBricknell, C
dc.contributor.authorSun, M
dc.contributor.authorGothard, L
dc.contributor.authorO'Brien, G
dc.contributor.authorCruz-Garcia, L
dc.contributor.authorBadie, C
dc.contributor.authorAinsbury, E
dc.contributor.authorSomaiah, N
dc.date.accessioned2018-10-10T11:50:25Z
dc.date.issued2018-09-20
dc.identifier.citationRadiation research, 2018, 190 (6), pp. 596 - 604
dc.identifier.issn0033-7587
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2893
dc.identifier.eissn1938-5404
dc.identifier.doi10.1667/rr15116.1
dc.description.abstractThe RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy patient responses to ionizing radiation. In parallel, for validation purposes, this study incorporated conventional biomarkers of radiation exposure, including the dicentric assay. Peripheral blood samples were taken with ethical approval and informed consent from a total of 20 patients undergoing external beam radiotherapy for breast, lung, gastrointestinal or genitourinary tumors. For the dicentric assay, two samples were taken from each patient: prior to radiotherapy and before the final fraction. Blood samples were set up using standard methods for the dicentric assay. All the baseline samples had dicentric frequencies consistent with the expected background for the normal population. For blood taken before the final fraction, all the samples displayed distributions of aberrations, which are indicative of partial-body exposures. Whole-body and partial-body cytogenetic doses were calculated with reference to a 250-kVp X-ray calibration curve and then compared to the dose to blood derived using two newly developed blood dosimetric models. Initial comparisons indicated that the relationship between these measures of dose appear very promising, with a correlation of 0.88 (P = 0.001). A new Bayesian zero-inflated Poisson finite mixture method was applied to the dicentric data, and partial-body dose estimates showed no significant difference (P > 0.999) from those calculated by the contaminated Poisson technique. The next step will be further development and validation in a larger patient group.
dc.formatPrint-Electronic
dc.format.extent596 - 604
dc.languageeng
dc.language.isoeng
dc.publisherRADIATION RESEARCH SOC
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectChromosomes
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGastrointestinal Neoplasms
dc.subjectLung Neoplasms
dc.subjectUrogenital Neoplasms
dc.subjectChromosome Aberrations
dc.subjectBayes Theorem
dc.subjectRadiometry
dc.subjectRadiation Dosage
dc.subjectDose-Response Relationship, Radiation
dc.subjectRadiation, Ionizing
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectBiomarkers, Tumor
dc.titleDicentric Dose Estimates for Patients Undergoing Radiotherapy in the RTGene Study to Assess Blood Dosimetric Models and the New Bayesian Method for Gradient Exposure.
dc.typeJournal Article
dcterms.dateAccepted2018-08-24
rioxxterms.versionofrecord10.1667/rr15116.1
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2018-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfRadiation research
pubs.issue6
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Breast Radiobiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Breast Radiobiology
pubs.publication-statusPublished
pubs.volume190
pubs.embargo.termsNot known
icr.researchteamTranslational Breast Radiobiology
dc.contributor.icrauthorGothard, Lone
dc.contributor.icrauthorSomaiah, Navita


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