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dc.contributor.authorMoquet, Jen_US
dc.contributor.authorHigueras, Men_US
dc.contributor.authorDonovan, Een_US
dc.contributor.authorBoyle, Sen_US
dc.contributor.authorBarnard, Sen_US
dc.contributor.authorBricknell, Cen_US
dc.contributor.authorSun, Men_US
dc.contributor.authorGothard, Len_US
dc.contributor.authorO'Brien, Gen_US
dc.contributor.authorCruz-Garcia, Len_US
dc.contributor.authorBadie, Cen_US
dc.contributor.authorAinsbury, Een_US
dc.contributor.authorSomaiah, Nen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-10-10T11:50:25Z
dc.date.issued2018-09-20en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30234457en_US
dc.identifier.citationRadiat Res, 2018en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2893
dc.identifier.eissn1938-5404en_US
dc.identifier.doi10.1667/RR15116.1en_US
dc.description.abstractThe RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy patient responses to ionizing radiation. In parallel, for validation purposes, this study incorporated conventional biomarkers of radiation exposure, including the dicentric assay. Peripheral blood samples were taken with ethical approval and informed consent from a total of 20 patients undergoing external beam radiotherapy for breast, lung, gastrointestinal or genitourinary tumors. For the dicentric assay, two samples were taken from each patient: prior to radiotherapy and before the final fraction. Blood samples were set up using standard methods for the dicentric assay. All the baseline samples had dicentric frequencies consistent with the expected background for the normal population. For blood taken before the final fraction, all the samples displayed distributions of aberrations, which are indicative of partial-body exposures. Whole-body and partial-body cytogenetic doses were calculated with reference to a 250-kVp X-ray calibration curve and then compared to the dose to blood derived using two newly developed blood dosimetric models. Initial comparisons indicated that the relationship between these measures of dose appear very promising, with a correlation of 0.88 ( P = 0.001). A new Bayesian zero-inflated Poisson finite mixture method was applied to the dicentric data, and partial-body dose estimates showed no significant difference ( P > 0.999) from those calculated by the contaminated Poisson technique. The next step will be further development and validation in a larger patient group.en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.titleDicentric Dose Estimates for Patients Undergoing Radiotherapy in the RTGene Study to Assess Blood Dosimetric Models and the New Bayesian Method for Gradient Exposure.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-08-24en_US
rioxxterms.versionofrecord10.1667/RR15116.1en_US
rioxxterms.licenseref.startdate2018-09-20en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfRadiat Resen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Yarnold)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.publication-statusPublished onlineen_US
pubs.embargo.termsNot knownen_US
icr.researchteamClinical Academic Radiotherapy (Yarnold)en_US
icr.researchteamTargeted Therapyen_US
dc.contributor.icrauthorSomaiah, Navitaen_US
dc.contributor.icrauthorGothard, Loneen_US


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