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dc.contributor.authorJones, RL
dc.contributor.authorLe Cesne, A
dc.contributor.authorIbrahim, T
dc.contributor.authorGarcia Del Muro, X
dc.contributor.authorMenge, F
dc.date.accessioned2018-11-14T09:04:17Z
dc.date.issued2018-12
dc.identifier.citationExpert review of anticancer therapy, 2018, 18 (12), pp. 1241 - 1248
dc.identifier.issn1473-7140
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2922
dc.identifier.eissn1744-8328
dc.identifier.doi10.1080/14737140.2018.1524298
dc.description.abstractIntroduction Health-related quality of life (HRQoL) is a patient-reported outcome that addresses patients' perceptions of symptoms across physical, emotional, cognitive and social domains. As HRQoL is currently rarely measured outside clinical trials in oncology, it must be inferred from patients' everyday performance during treatment. To gain insight into the HRQoL of advanced STS patients receiving palliative treatment in clinical practice, three case studies of patients treated with trabectedin are examined. Areas covered: The patient in Case 1 has maintained complete remission for more than 8 years after receiving nine cycles of second-line trabectedin followed by secondary surgery for recurrent myxoid liposarcoma, and was able to resume normal activities during trabectedin treatment. Case 2 describes 10 years' follow-up of a patient with myxoid liposarcoma who remains well after many lines of chemotherapy including extended use of trabectedin in the second line. The third case illustrates the feasibility of extending survival time in an elderly patient with metastatic leiomyosarcoma who was able to maintain a busy and active lifestyle while receiving second-line trabectedin. Expert commentary: Owing to its relatively benign safety profile, trabectedin frequently permits prolonged therapy and is generally well tolerated, often allowing patients to carry on with normal daily activities.
dc.formatPrint-Electronic
dc.format.extent1241 - 1248
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectHumans
dc.subjectLiposarcoma, Myxoid
dc.subjectLeiomyosarcoma
dc.subjectSarcoma
dc.subjectAntineoplastic Agents, Alkylating
dc.subjectQuality of Life
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectPatient Reported Outcome Measures
dc.subjectTrabectedin
dc.titlePreserving quality of life as a key treatment goal in advanced soft tissue sarcomas.
dc.typeJournal Article
rioxxterms.versionofrecord10.1080/14737140.2018.1524298
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2018-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfExpert review of anticancer therapy
pubs.issue12
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume18
pubs.embargo.termsNot known
icr.researchteamSarcoma Clinical Trials (R Jones)en_US
dc.contributor.icrauthorJones, Robinen


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