Preserving quality of life as a key treatment goal in advanced soft tissue sarcomas.
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Date
2018-12ICR Author
Author
Jones, RL
Le Cesne, A
Ibrahim, T
Garcia Del Muro, X
Menge, F
Type
Journal Article
Metadata
Show full item recordAbstract
Introduction Health-related quality of life (HRQoL) is a patient-reported outcome that addresses patients' perceptions of symptoms across physical, emotional, cognitive and social domains. As HRQoL is currently rarely measured outside clinical trials in oncology, it must be inferred from patients' everyday performance during treatment. To gain insight into the HRQoL of advanced STS patients receiving palliative treatment in clinical practice, three case studies of patients treated with trabectedin are examined. Areas covered: The patient in Case 1 has maintained complete remission for more than 8 years after receiving nine cycles of second-line trabectedin followed by secondary surgery for recurrent myxoid liposarcoma, and was able to resume normal activities during trabectedin treatment. Case 2 describes 10 years' follow-up of a patient with myxoid liposarcoma who remains well after many lines of chemotherapy including extended use of trabectedin in the second line. The third case illustrates the feasibility of extending survival time in an elderly patient with metastatic leiomyosarcoma who was able to maintain a busy and active lifestyle while receiving second-line trabectedin. Expert commentary: Owing to its relatively benign safety profile, trabectedin frequently permits prolonged therapy and is generally well tolerated, often allowing patients to carry on with normal daily activities.
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Subject
Humans
Liposarcoma, Myxoid
Leiomyosarcoma
Sarcoma
Antineoplastic Agents, Alkylating
Quality of Life
Adult
Aged
Female
Male
Young Adult
Patient Reported Outcome Measures
Trabectedin
Research team
Sarcoma Clinical Trials (R Jones)
Language
eng
License start date
2018-12
Citation
Expert review of anticancer therapy, 2018, 18 (12), pp. 1241 - 1248