dc.contributor.author | Alvarez, RM | |
dc.contributor.author | Biliatis, I | |
dc.contributor.author | Rockall, A | |
dc.contributor.author | Papadakou, E | |
dc.contributor.author | Sohaib, SA | |
dc.contributor.author | deSouza, NM | |
dc.contributor.author | Butler, J | |
dc.contributor.author | Nobbenhuis, M | |
dc.contributor.author | Barton, D | |
dc.contributor.author | Shepherd, JH | |
dc.contributor.author | Ind, T | |
dc.date.accessioned | 2018-11-14T09:32:02Z | |
dc.date.issued | 2018-12-01 | |
dc.identifier.citation | BJOG : an international journal of obstetrics and gynaecology, 2018, 125 (13), pp. 1726 - 1733 | |
dc.identifier.issn | 1470-0328 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2927 | |
dc.identifier.eissn | 1471-0528 | |
dc.identifier.doi | 10.1111/1471-0528.15429 | |
dc.description.abstract | OBJECTIVE: To determine the association between the residual cervix measured on postoperative MRI after radical vaginal trachelectomy (RVT) and adverse obstetrical outcomes. DESIGN: Observational study. SETTING: Referral Cancer centre. POPULATION: Women who conceived after RVT for cervical cancer at the Royal Marsden Hospital, London, between 1995 and 2015. METHODS: Postoperative MRI scans were analysed by three researchers. The agreement between researchers was assessed by Pearson's correlation coefficient and Bland-Altman plot. Patients were divided into two groups (<10 and ≥10 mm residual cervix) for the analysis of adverse obstetrical outcomes. MAIN OUTCOME MEASURES: Late miscarriage, premature delivery, premature rupture of membranes (PROM) and chorioamnionitis. RESULTS: Thirty-one MRI scans were available; 29 of these women had a pregnancy that progressed beyond the first trimester. There was a strong reproducibility of the measurement of residual cervix (P < 0.001). Nineteen women (65.5%) had <10 mm residual cervix and 10 (34.5%) had ≥10 mm. Among women with <10 mm residual cervix, seven (36.8%) experienced PROM and ten (66.7%) had a preterm birth; No women with ≥10 mm residual cervix had PROM and two (22.2%) had a preterm birth (P = 0.028 and P = 0.035, respectively). Overall, there were nine (16.7%) first-trimester miscarriages, six (11.1%) late fetal losses, 12 (31.6%) preterm births and 36 (66.7%) live births. After a mean follow up of 78.1 months, 36 women were disease-free and one woman had died. CONCLUSIONS: MRI measurements of the residual cervix are reproducible between observers. The incidence of PROM and premature delivery is higher when the residual cervix after RVT is <10 mm. TWEETABLE ABSTRACT: The risk of prematurity after RVT can be predicted from measurements of residual cervical length on postoperative MRI scan. | |
dc.format | Print-Electronic | |
dc.format.extent | 1726 - 1733 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.rights.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
dc.subject | Cervix Uteri | |
dc.subject | Humans | |
dc.subject | Abortion, Spontaneous | |
dc.subject | Chorioamnionitis | |
dc.subject | Fetal Membranes, Premature Rupture | |
dc.subject | Premature Birth | |
dc.subject | Observer Variation | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Organ Size | |
dc.subject | Pregnancy Outcome | |
dc.subject | Risk Factors | |
dc.subject | Reproducibility of Results | |
dc.subject | Gestational Age | |
dc.subject | Pregnancy | |
dc.subject | Adult | |
dc.subject | Uterine Cervical Neoplasms | |
dc.subject | Female | |
dc.subject | Young Adult | |
dc.subject | Fertility Preservation | |
dc.subject | Trachelectomy | |
dc.title | MRI measurement of residual cervical length after radical trachelectomy for cervical cancer and the risk of adverse pregnancy outcomes: a blinded imaging analysis. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-07-16 | |
rioxxterms.versionofrecord | 10.1111/1471-0528.15429 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | BJOG : an international journal of obstetrics and gynaecology | |
pubs.issue | 13 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.publication-status | Published | |
pubs.volume | 125 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | deSouza, Nandita | |