dc.contributor.author | Huis In 't Veld, EA | |
dc.contributor.author | Grünhagen, DJ | |
dc.contributor.author | Deroose, JP | |
dc.contributor.author | Nijsten, TEC | |
dc.contributor.author | Wouters, MWJM | |
dc.contributor.author | Verhoef, C | |
dc.contributor.author | van Houdt, WJ | |
dc.contributor.author | Hayes, AJ | |
dc.date.accessioned | 2018-11-30T09:09:49Z | |
dc.date.issued | 2018-08 | |
dc.identifier.citation | British journal of cancer, 2018, 119 (4), pp. 429 - 434 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2964 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/s41416-018-0149-z | |
dc.description.abstract | Background A small minority of patients present with locally advanced cutaneous Squamous Cell Carcinoma (cSCC). The aim of this study was to evaluate the effectiveness of Tumour necrosis factor α (TNF) and melphalan based isolated limb perfusion (TM-ILP) as a limb saving strategy for locally advanced extremity cSCC.Methods A retrospective search from prospectively maintained databases, at two tertiary referral centers, was performed to identify patients treated with TM-ILP for locally advanced cSSC of an extremity between 2000 and 2015.Results A total of 30 patients treated with TM-ILP for cSCC were identified, with a median age of 71 years (36-92) and 50% female. Response could not be evaluated in 3 patients. After a median follow up of 25 months, the overall response rate was 81% (n = 22), with 16 patients having a complete response (CR, 59%). A total of 7 patients developed local recurrence, with a median time to recurrence of 9 months (Interquartile Range 7-10). Progressive disease was observed in 5 patients (19%). Limb salvage rate was 80%. The overall 2-year survival was 67%.Conclusions TM-ILP should be considered as an option in patients with locally advanced cSCC in specialised centers, resulting in a high limb salvage rate. | |
dc.format | Print-Electronic | |
dc.format.extent | 429 - 434 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Lower Extremity | |
dc.subject | Humans | |
dc.subject | Carcinoma, Squamous Cell | |
dc.subject | Skin Neoplasms | |
dc.subject | Melphalan | |
dc.subject | Tumor Necrosis Factor-alpha | |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | |
dc.subject | Treatment Outcome | |
dc.subject | Limb Salvage | |
dc.subject | Survival Analysis | |
dc.subject | Retrospective Studies | |
dc.subject | Perfusion | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Tertiary Care Centers | |
dc.title | Isolated limb perfusion for unresectable extremity cutaneous squamous cell carcinoma; an effective limb saving strategy. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-05-22 | |
rioxxterms.versionofrecord | 10.1038/s41416-018-0149-z | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-08 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | British journal of cancer | |
pubs.issue | 4 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery | |
pubs.publication-status | Published | |
pubs.volume | 119 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Sarcoma and Melanoma Surgery | en_US |
dc.contributor.icrauthor | Hayes, Andrew | |