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dc.contributor.authorBedford, JL
dc.contributor.authorZiegenhein, P
dc.contributor.authorNill, S
dc.contributor.authorOelfke, U
dc.date.accessioned2018-12-21T12:15:01Z
dc.date.issued2018-12-20
dc.identifier.citationMedical engineering & physics, 2019, 64 pp. 28 - 36
dc.identifier.issn1350-4533
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2985
dc.identifier.eissn1873-4030
dc.identifier.doi10.1016/j.medengphy.2018.12.011
dc.description.abstractThe Cyberknife system (Accuray Inc., Sunnyvale, CA) enables radiotherapy using stereotactic ablative body radiotherapy (SABR) with a large number of non-coplanar beam orientations. Recently, a multileaf collimator has also been available to allow flexibility in field shaping. This work aims to evaluate the quality of treatment plans obtainable with the multileaf collimator. Specifically, the aim is to find a subset of beam orientations from a predetermined set of candidate directions, such that the treatment quality is maintained but the treatment time is reduced. An evolutionary algorithm is used to successively refine a randomly selected starting set of beam orientations. By using an efficient computational framework, clinically useful solutions can be found in several hours. It is found that 15 beam orientations are able to provide treatment quality which approaches that of the candidate beam set of 110 beam orientations, but with approximately half of the estimated treatment time. Choice of an efficient subset of beam orientations offers the possibility to improve the patient experience and maximise the number of patients treated.
dc.formatPrint-Electronic
dc.format.extent28 - 36
dc.languageeng
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectRadiosurgery
dc.subjectRadiotherapy Planning, Computer-Assisted
dc.subjectQuality Control
dc.titleBeam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation.
dc.typeJournal Article
dcterms.dateAccepted2018-12-12
rioxxterms.versionofrecord10.1016/j.medengphy.2018.12.011
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2019-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMedical engineering & physics
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning/Radiotherapy treatment planning (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy treatment planning/Radiotherapy treatment planning (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume64
pubs.embargo.termsNo embargo
icr.researchteamRadiotherapy Physics Modelling
icr.researchteamRadiotherapy treatment planning
dc.contributor.icrauthorNill, Simeon


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