Toward personalized treatment in multiple myeloma based on molecular characteristics.
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Date
2019-02-14ICR Author
Author
Pawlyn, C
Davies, FE
Type
Journal Article
Metadata
Show full item recordAbstract
To date, the choice of therapy for an individual multiple myeloma patient has been based on clinical factors such as age and comorbidities. The widespread evolution, validation, and clinical utilization of molecular technologies, such as fluorescence in situ hybridization and next-generation sequencing has enabled the identification of a number of prognostic and predictive biomarkers for progression-free survival, overall survival, and treatment response. In this review, we argue that in order to continue to improve myeloma patient outcomes incorporating such biomarkers into the routine diagnostic workup of patients will allow for the use of personalized, biologically based treatments.
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Subject
Humans
Multiple Myeloma
Combined Modality Therapy
High-Throughput Nucleotide Sequencing
Biomarkers, Tumor
Precision Medicine
Research team
Myeloma Biology and Therapeutics
Language
eng
Date accepted
2018-10-30
License start date
2019-02
Citation
Blood, 2019, 133 (7), pp. 660 - 675
Publisher
AMER SOC HEMATOLOGY