Show simple item record

dc.contributor.authorMartinho Costa, Men_US
dc.contributor.authorShah, Aen_US
dc.contributor.authorRivens, Ien_US
dc.contributor.authorBox, Cen_US
dc.contributor.authorO'Shea, Ten_US
dc.contributor.authorPapaevangelou, Een_US
dc.contributor.authorBamber, Jen_US
dc.contributor.authorTer Haar, Gen_US
dc.coverage.spatialGermanyen_US
dc.date.accessioned2019-02-15T15:04:35Z
dc.date.issued2019-03en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30581729en_US
dc.identifierS2213-5979(18)30015-6en_US
dc.identifier.citationPhotoacoustics, 2019, 13 pp. 53 - 65en_US
dc.identifier.issn2213-5979en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3050
dc.identifier.doi10.1016/j.pacs.2018.12.002en_US
dc.description.abstractPhotoacoustic imaging (PAI) provides information on haemoglobin levels and blood oxygenation (sO2). To facilitate assessment of the variability in sO2 and haemoglobin in tumours, for example in response to therapies, the baseline variability of these parameters was evaluated in subcutaneous head and neck tumours in mice, using a PAI system (MSOTinVision-256TF). Tumours of anaesthetized animals (midazolam-fentanyl-medetomidine) were imaged for 75 min, in varying positions, and repeatedly over 6 days. An increasing linear trend for average tumoural haemoglobin and blood sO2 was observed, when imaging over 75 min. There were no significant differences in these temporal trends, when repositioning tumours. A negative correlation was found between the percent decrease in blood sO2 over 6 days and tumour growth rate. This paper shows the potential of PAI to provide baseline data for assessing the significance of intra- and inter-tumoural variations that may eventually have value for predicting and/or monitoring cancer treatment response.en_US
dc.format.extent53 - 65en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBlood sO2en_US
dc.subjectHead and neck subcutaneous tumoursen_US
dc.subjectHemoglobinen_US
dc.subjectHypoxiaen_US
dc.subjectPhotoacoustic imagingen_US
dc.subjectPimonidazoleen_US
dc.titleQuantitative photoacoustic imaging study of tumours in vivo: Baseline variations in quantitative measurements.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-12-06en_US
rioxxterms.versionofrecord10.1016/j.pacs.2018.12.002en_US
rioxxterms.licenseref.startdate2019-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfPhotoacousticsen_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Ultrasound & Optical Imaging
pubs.publication-statusPublished onlineen_US
pubs.volume13en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamRadiotherapy Physics Modellingen_US
icr.researchteamTherapeutic Ultrasounden_US
icr.researchteamUltrasound & Optical Imagingen_US
dc.contributor.icrauthorBamber, Jeffreyen_US
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthorRivens, Ianen_US
dc.contributor.icrauthorBox, Carolen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/