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dc.contributor.authorPathmanathan, AUen_US
dc.contributor.authorMcNair, HAen_US
dc.contributor.authorSchmidt, MAen_US
dc.contributor.authorBrand, DHen_US
dc.contributor.authorDelacroix, Len_US
dc.contributor.authorEccles, CLen_US
dc.contributor.authorGordon, Aen_US
dc.contributor.authorHerbert, Ten_US
dc.contributor.authorvan As, NJen_US
dc.contributor.authorHuddart, RAen_US
dc.contributor.authorTree, ACen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-02-15T16:08:05Z
dc.date.issued2019-03en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30676772en_US
dc.identifier.citationBr J Radiol, 2019, 92 (1095), pp. 20180948 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3054
dc.identifier.eissn1748-880Xen_US
dc.identifier.doi10.1259/bjr.20180948en_US
dc.description.abstractOBJECTIVE:: With increasing incorporation of MRI in radiotherapy, we investigate two MRI sequences for prostate delineation in radiographer-led image guidance. METHODS:: Five therapeutic radiographers contoured the prostate individually on CT, T2 weighted (T2W) and T2* weighted (T2*W) imaging for 10 patients. Contours were analysed with Monaco ADMIRE (research v. 2.0) to assess interobserver variability and accuracy by comparison with a gold standard clinician contour. Observers recorded time taken for contouring and scored image quality and confidence in contouring. RESULTS:: There is good agreement when comparing radiographer contours to the gold-standard for all three imaging types with Dice similarity co-efficient 0.91-0.94, Cohen's κ 0.85-0.91, Hausdorff distance 4.6-7.6 mm and mean distance between contours 0.9-1.2 mm. In addition, there is good concordance between radiographers across all imaging modalities. Both T2W and T2*W MRI show reduced interobserver variability and improved accuracy compared to CT, this was statistically significant for T2*W imaging compared to CT across all four comparison metrics. Comparing MRI sequences reveals significantly reduced interobserver variability and significantly improved accuracy on T2*W compared to T2W MRI for DSC and Cohen's κ. Both MRI sequences scored significantly higher compared to CT for image quality and confidence in contouring, particularly T2*W. This was also reflected in the shorter time for contouring, measuring 15.4, 9.6 and 9.8 min for CT, T2W and T2*W MRI respectively. Conclusion: Therapeutic radiographer prostate contours are more accurate, show less interobserver variability and are more confidently and quickly outlined on MRI compared to CT, particularly using T2*W MRI. Advances in knowledge: Our work is relevant for MRI sequence choice and development of the roles of the interprofessional team in the advancement of MRI-guided radiotherapy.en_US
dc.format.extent20180948 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectHumansen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectMaleen_US
dc.subjectMultimodal Imagingen_US
dc.subjectObserver Variationen_US
dc.subjectProstateen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectRadiotherapy Planning, Computer-Assisteden_US
dc.subjectRadiotherapy, Image-Guideden_US
dc.subjectTomography, X-Ray Computeden_US
dc.titleComparison of prostate delineation on multimodality imaging for MR-guided radiotherapy.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-12-18en_US
rioxxterms.versionofrecord10.1259/bjr.20180948en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
rioxxterms.licenseref.startdate2019-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBr J Radiolen_US
pubs.issue1095en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Stereotactic and Precision Body Radiotherapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Stereotactic and Precision Body Radiotherapy/Stereotactic and Precision Body Radiotherapy (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume92en_US
pubs.embargo.termsNot knownen_US
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
icr.researchteamStereotactic and Precision Body Radiotherapyen_US
dc.contributor.icrauthorHuddart, Roberten_US
dc.contributor.icrauthorvan As, Nicken_US
dc.contributor.icrauthorTree, Alisonen_US
dc.contributor.icrauthorBrand, Douglasen_US


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