Quality of life of patients with locally advanced head and neck cancer treated with induction chemotherapy followed by cisplatin-containing chemoradiotherapy in the Dutch CONDOR study: a randomized controlled trial.
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Date
2018-04ICR Author
Author
Driessen, CML
Groenewoud, JMM
de Boer, JP
Gelderblom, H
van der Graaf, WTA
Prins, JB
Kaanders, JHAM
van Herpen, CML
Type
Journal Article
Metadata
Show full item recordAbstract
PURPOSE:The CONDOR study showed that docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with cisplatin 100 mg/m2 on days 1, 22, and 43 (cis100 + RT; n = 27)) versus accelerated radiotherapy with cisplatin weekly 40 mg/m2 (cis40 + ART; n = 29) in locally advanced head and neck cancer (LAHNC) patients was not feasible. Here, we report the analysis of health-related quality of life (HRQOL) of the patients entered in this study. METHODS:HRQOL was assessed at baseline, after two TPF, before start of chemoradiotherapy, and 1, 4, 8, 12, and 24 months after completion of chemoradiotherapy using the EORTC-QLQ-C30 and QLQ-H&N35 in 62 patients. RESULTS:Compliance with the QOL questionnaires was 94% (59/62) at baseline and 61% (30/49) at 12 months, respectively. HRQOL decreased after TPF and further decreased during chemoradiohteray in both arms equally. Pain and swallowing dysfunction improved significantly during TPF but deteriorated below baseline levels during chemoradiotherapy, cis40 + ART > cis100 + RT (p < 0.05). HRQOL and symptoms restored to baseline within 12 months in both arms and remained at that level until 24 months. CONCLUSIONS:After TPF, cis40 + ART had a larger negative impact on symptoms than cis100 + RT, probably due to the ART. HRQOL and symptoms restored to baseline levels within 12 months after end of treatment in both arms, which is an important perspective for patients during the phase of most serious acute side effects of treatment. TRIAL REGISTRATION:NCT00774319.
Collections
Subject
Humans
Head and Neck Neoplasms
Cisplatin
Fluorouracil
Antineoplastic Combined Chemotherapy Protocols
Feasibility Studies
Quality of Life
Adult
Aged
Middle Aged
Female
Male
Chemoradiotherapy
Induction Chemotherapy
Docetaxel
Research team
Clinical and Translational Sarcoma
Language
eng
Date accepted
2017-10-23
License start date
2018-04
Citation
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018, 26 (4), pp. 1233 - 1242