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dc.contributor.authorHallin, Men_US
dc.contributor.authorMiki, Yen_US
dc.contributor.authorHayes, AJen_US
dc.contributor.authorJones, RLen_US
dc.contributor.authorFisher, Cen_US
dc.contributor.authorThway, Ken_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-03-04T15:45:46Z
dc.date.issued2018en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29977483en_US
dc.identifier10.1177_2036361318782626en_US
dc.identifier.citationRare Tumors, 2018, 10 pp. 2036361318782626 - ?en_US
dc.identifier.issn2036-3605en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3129
dc.identifier.doi10.1177/2036361318782626en_US
dc.description.abstractMyxoinflammatory fibroblastic sarcoma is a rare malignant soft tissue neoplasm that typically arises on the distal extremities of adults. It usually behaves in a low-grade manner and its characteristic histology is of a lobulated proliferation of moderately atypical spindled to epithelioid cells, vacuolated cells, and enlarged or bizarre cells with prominent nucleoli, dispersed within myxoid stroma containing a mixed inflammatory cell infiltrate. The etiology of myxoinflammatory fibroblastic sarcoma remains unknown with no definite causal factors identified. We describe a case of myxoinflammatory fibroblastic sarcoma arising in the foot of a 77-year-old female, which rapidly recurred locally after initial excision and which arose 10 years after renal transplantation. The neoplasm also showed intermingled areas of hemosiderotic fibrolipomatous tumor. The patient also had multifocal areas of squamous cell carcinoma in situ of the foot and hand, in keeping with the clinical context of immune deficiency. This is the second case of myxoinflammatory fibroblastic sarcoma reported to occur after transplantation, but additionally shows hybrid features of hemosiderotic fibrolipomatous tumor, highlights immunocompromise/immunosuppressive therapy as a possible etiologic factor in their development, and adds to the growing number of myxoinflammatory fibroblastic sarcoma that has demonstrated aggressive behavior.en_US
dc.format.extent2036361318782626 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectMyxoinflammatory fibroblastic sarcomaen_US
dc.subjectetiologyen_US
dc.subjectfooten_US
dc.subjecthemosiderotic fibrolipomatous tumoren_US
dc.subjecthybriden_US
dc.subjectimmune deficiencyen_US
dc.subjectimmunocompromiseden_US
dc.subjectpathologyen_US
dc.subjectrenal transplanten_US
dc.titleAcral myxoinflammatory fibroblastic sarcoma with hybrid features of hemosiderotic fibrolipomatous tumor occurring 10 years after renal transplantation.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-05-03en_US
rioxxterms.versionofrecord10.1177/2036361318782626en_US
rioxxterms.licenseref.startdate2018en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfRare Tumorsen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished onlineen_US
pubs.volume10en_US
pubs.embargo.termsNot knownen_US
icr.researchteamSarcoma Clinical Trials (R Jones)en_US
icr.researchteamSarcoma and Melanoma Surgeryen_US
dc.contributor.icrauthorFisher, Cyrilen_US
dc.contributor.icrauthorHayes, Andrewen_US
dc.contributor.icrauthorJones, Robinen_US


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