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dc.contributor.authorKühnl, Aen_US
dc.contributor.authorCunningham, Den_US
dc.contributor.authorHutka, Men_US
dc.contributor.authorPeckitt, Cen_US
dc.contributor.authorRozati, Hen_US
dc.contributor.authorMorano, Fen_US
dc.contributor.authorChong, Ien_US
dc.contributor.authorGillbanks, Aen_US
dc.contributor.authorWotherspoon, Aen_US
dc.contributor.authorHarris, Men_US
dc.contributor.authorMurray, Ten_US
dc.contributor.authorChau, Ien_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-03-04T16:17:36Z
dc.date.issued2018en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30128155en_US
dc.identifier109en_US
dc.identifier.citationBMC Hematol, 2018, 18 pp. 19 - ?en_US
dc.identifier.issn2052-1839en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3132
dc.identifier.doi10.1186/s12878-018-0109-0en_US
dc.description.abstractBackground: In patients presenting with peripheral lymphadenopathy, it is critical to effectively identify those with underlying cancer who require urgent specialist care. Methods: We analyzed a large dataset of 1000 consecutive patients with unexplained lymphadenopathy referred between 2001 and 2009 to the Royal Marsden Hospital (RMH) rapid access lymph node diagnostic clinic (LNDC). Results: Cancer was diagnosed in 14% of patients. Factors predictive for malignant disease were male sex, age, supraclavicular and multiple site involvement. Cancer-associated symptoms were present for a median of 8 weeks. The median time from referral to start of cancer therapy was 53 days. Fine needle aspiration (FNA) was performed in 83% of patients with malignancies. Sensitivity and specificity of FNA were limited (50 and 87%, respectively for any malignancy; 30 and 79%, respectively for lymphoma). The vast majority of cancer patients received diagnostic biopsies on the basis of suspicious clinical and ultrasound findings; the FNA result contributed to establishing the diagnosis in only 4 cases. Conclusions: In conclusion, we demonstrate that Oncologist-led rapid access clinics are successful concepts to assess patients with unexplained lymphadenopathy. Our data suggest that a routine use of FNA should be reconsidered in this setting.en_US
dc.format.extent19 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCancer diagnosisen_US
dc.subjectLymphadenopathyen_US
dc.subjectRapid access clinicen_US
dc.titleRapid access clinic for unexplained lymphadenopathy and suspected malignancy: prospective analysis of 1000 patients.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-06-25en_US
rioxxterms.versionofrecord10.1186/s12878-018-0109-0en_US
rioxxterms.licenseref.startdate2018en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBMC Hematolen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished onlineen_US
pubs.volume18en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMedicine (RMH Smith Cunningham)en_US
dc.contributor.icrauthorCunningham, Daviden_US
dc.contributor.icrauthorChau, Ianen_US


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