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dc.contributor.authorKhokhlova, T
dc.contributor.authorRosnitskiy, P
dc.contributor.authorHunter, C
dc.contributor.authorMaxwell, A
dc.contributor.authorKreider, W
dc.contributor.authorTer Haar, G
dc.contributor.authorCosta, M
dc.contributor.authorSapozhnikov, O
dc.contributor.authorKhokhlova, V
dc.date.accessioned2019-03-18T10:16:28Z
dc.date.issued2018-09
dc.identifier.citationThe Journal of the Acoustical Society of America, 2018, 144 (3), pp. 1160 - ?
dc.identifier.issn0001-4966
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3156
dc.identifier.eissn1520-8524
dc.identifier.doi10.1121/1.5052260
dc.description.abstractPulsed high intensity focused ultrasound was shown to enhance chemotherapeutic drug uptake in tumor tissue through inertial cavitation, which is commonly assumed to require peak rarefactional pressures to exceed a certain threshold. However, recent studies have indicated that inertial cavitation activity also correlates with the presence of shocks at the focus. The shock front amplitude and corresponding peak negative pressure ( p - ) in the focal waveform are primarily determined by the transducer F -number: less focused transducers produce shocks at lower p - . Here, the dependence of inertial cavitation activity on the transducer F -number was investigated in agarose gel by monitoring broadband noise emissions with a coaxial passive cavitation detector (PCD) during pulsed exposures (pulse duration 1 ms, pulse repetition frequency 1 Hz) with p - varying within 1-15 MPa. Three 1.5 MHz transducers with the same aperture, but different focal distances ( F -numbers 0.77, 1.02, 1.52) were used. PCD signals were processed to extract cavitation probability, persistence, and mean noise level. At the same p - , all metrics indicated enhanced cavitation activity at higher F -numbers; specifically, cavitation probability reached 100% when shocks formed at the focus. These results provide further evidence supporting the excitation of inertial cavitation at reduced p - by waveforms with nonlinear distortion and shocks.
dc.formatPrint
dc.format.extent1160 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectOscillometry
dc.subjectTransducers
dc.subjectModels, Biological
dc.subjectUltrasonic Waves
dc.titleDependence of inertial cavitation induced by high intensity focused ultrasound on transducer <i>F</i>-number and nonlinear waveform distortion.
dc.typeJournal Article
rioxxterms.versionofrecord10.1121/1.5052260
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfThe Journal of the Acoustical Society of America
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.publication-statusPublished
pubs.volume144
pubs.embargo.termsNot known
icr.researchteamTherapeutic Ultrasounden_US
dc.contributor.icrauthorTer Haar, Gailen


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