Noncoding RNA in Cholangiocarcinoma.
View/ Open
Date
2019-02-01ICR Author
Author
Salati, M
Braconi, C
Type
Journal Article
Metadata
Show full item recordAbstract
Cholangiocarcinomas (CCAs) are tumors with a dismal prognosis. Early diagnosis is a key challenge because of the lack of specific symptoms, and the curability rate is low due to the difficulty in achieving a radical resection and the intrinsic chemoresistance of CCA cells. Noncoding RNAs (ncRNAs) are transcripts that are not translated into proteins but exert their functional role by regulating the transcription and translation of other genes. The discovery of the first ncRNA dates back to 1993 when the microRNA (miRNA) lin-4 was discovered in Caenorhabditis elegans. Only 10 years later, miRNAs were shown to play an oncogenic role in cancer cells and within 20 years miRNA therapeutics were tested in humans. Here, the authors review the latest evidence for a role for ncRNAs in CCA and discuss the promise and challenges associated with the introduction of ncRNAs into clinical practice.
Collections
Subject
Humans
Cholangiocarcinoma
Bile Duct Neoplasms
Liver Neoplasms
MicroRNAs
Gene Expression Regulation, Neoplastic
Tumor Microenvironment
RNA, Long Noncoding
Carcinogenesis
Research team
Signal Transduction & Molecular Pharmacology
Language
eng
License start date
2019-02
Citation
Seminars in liver disease, 2019, 39 (1), pp. 13 - 25
Publisher
THIEME MEDICAL PUBL INC