dc.contributor.author | van Kesteren, Z | |
dc.contributor.author | van der Horst, A | |
dc.contributor.author | Gurney-Champion, OJ | |
dc.contributor.author | Bones, I | |
dc.contributor.author | Tekelenburg, D | |
dc.contributor.author | Alderliesten, T | |
dc.contributor.author | van Tienhoven, G | |
dc.contributor.author | Klaassen, R | |
dc.contributor.author | van Laarhoven, HWM | |
dc.contributor.author | Bel, A | |
dc.date.accessioned | 2019-05-22T09:33:00Z | |
dc.date.issued | 2019-05-14 | |
dc.identifier.citation | Radiation oncology (London, England), 2019, 14 (1), pp. 80 - ? | |
dc.identifier.issn | 1748-717X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3235 | |
dc.identifier.eissn | 1748-717X | |
dc.identifier.doi | 10.1186/s13014-019-1279-z | |
dc.description.abstract | BACKGROUND: For radiotherapy of abdominal cancer, four-dimensional magnetic resonance imaging (4DMRI) is desirable for tumor definition and the assessment of tumor and organ motion. However, irregular breathing gives rise to image artifacts. We developed a outlier rejection strategy resulting in a 4DMRI with reduced image artifacts in the presence of irregular breathing. METHODS: We obtained 2D T2-weighted single-shot turbo spin echo images, with an interleaved 1D navigator acquisition to obtain the respiratory signal during free breathing imaging in 2 patients and 12 healthy volunteers. Prior to binning, upper and lower inclusion thresholds were chosen such that 95% of the acquired images were included, while minimizing the distance between the thresholds (inclusion range (IR)). We compared our strategy (Min95) with three commonly applied strategies: phase binning with all images included (Phase), amplitude binning with all images included (MaxIE), and amplitude binning with the thresholds set as the mean end-inhale and mean end-exhale diaphragm positions (MeanIE). We compared 4DMRI quality based on: Data included (DI); percentage of images remaining after outlier rejection. Reconstruction completeness (RC); percentage of bin-slice combinations containing at least one image after binning. Intra-bin variation (IBV); interquartile range of the diaphragm position within the bin-slice combination, averaged over three central slices and ten respiratory bins. IR. Image smoothness (S); quantified by fitting a parabola to the diaphragm profile in a sagittal plane of the reconstructed 4DMRI. A two-sided Wilcoxon's signed-rank test was used to test for significance in differences between the Min95 strategy and the Phase, MaxIE, and MeanIE strategies. RESULTS: Based on the fourteen subjects, the Min95 binning strategy outperformed the other strategies with a mean RC of 95.5%, mean IBV of 1.6 mm, mean IR of 15.1 mm and a mean S of 0.90. The Phase strategy showed a poor mean IBV of 6.2 mm and the MaxIE strategy showed a poor mean RC of 85.6%, resulting in image artifacts (mean S of 0.76). The MeanIE strategy demonstrated a mean DI of 85.6%. CONCLUSIONS: Our Min95 reconstruction strategy resulted in a 4DMRI with less artifacts and more precise diaphragm position reconstruction compared to the other strategies. TRIAL REGISTRATION: Volunteers: protocol W15_373#16.007; patients: protocol NL47713.018.14. | |
dc.format | Electronic | |
dc.format.extent | 80 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BMC | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Esophageal Neoplasms | |
dc.subject | Stomach Neoplasms | |
dc.subject | Pancreatic Neoplasms | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Prognosis | |
dc.subject | Radiotherapy Dosage | |
dc.subject | Radiotherapy Planning, Computer-Assisted | |
dc.subject | Artifacts | |
dc.subject | Case-Control Studies | |
dc.subject | Cohort Studies | |
dc.subject | Phantoms, Imaging | |
dc.subject | Respiration | |
dc.subject | Algorithms | |
dc.subject | Image Processing, Computer-Assisted | |
dc.subject | Adult | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Radiotherapy, Intensity-Modulated | |
dc.subject | Four-Dimensional Computed Tomography | |
dc.subject | Organs at Risk | |
dc.title | A novel amplitude binning strategy to handle irregular breathing during 4DMRI acquisition: improved imaging for radiotherapy purposes. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-04-22 | |
rioxxterms.versionofrecord | 10.1186/s13014-019-1279-z | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-05-14 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Radiation oncology (London, England) | |
pubs.issue | 1 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.publication-status | Published | |
pubs.volume | 14 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Radiotherapy Physics Modelling | |
dc.contributor.icrauthor | Gurney-Champion, Oliver | |