dc.contributor.author | Martínez-Vélez, N | |
dc.contributor.author | Garcia-Moure, M | |
dc.contributor.author | Marigil, M | |
dc.contributor.author | González-Huarriz, M | |
dc.contributor.author | Puigdelloses, M | |
dc.contributor.author | Gallego Pérez-Larraya, J | |
dc.contributor.author | Zalacaín, M | |
dc.contributor.author | Marrodán, L | |
dc.contributor.author | Varela-Guruceaga, M | |
dc.contributor.author | Laspidea, V | |
dc.contributor.author | Aristu, JJ | |
dc.contributor.author | Ramos, LI | |
dc.contributor.author | Tejada-Solís, S | |
dc.contributor.author | Díez-Valle, R | |
dc.contributor.author | Jones, C | |
dc.contributor.author | Mackay, A | |
dc.contributor.author | Martínez-Climent, JA | |
dc.contributor.author | García-Barchino, MJ | |
dc.contributor.author | Raabe, E | |
dc.contributor.author | Monje, M | |
dc.contributor.author | Becher, OJ | |
dc.contributor.author | Junier, MP | |
dc.contributor.author | El-Habr, EA | |
dc.contributor.author | Chneiweiss, H | |
dc.contributor.author | Aldave, G | |
dc.contributor.author | Jiang, H | |
dc.contributor.author | Fueyo, J | |
dc.contributor.author | Patiño-García, A | |
dc.contributor.author | Gomez-Manzano, C | |
dc.contributor.author | Alonso, MM | |
dc.date.accessioned | 2019-06-07T10:44:06Z | |
dc.date.issued | 2019-05-28 | |
dc.identifier.citation | Nature communications, 2019, 10 (1), pp. 2235 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3257 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-019-10043-0 | |
dc.description.abstract | Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic virotherapy is emerging as a solid therapeutic approach. Delta-24-RGD is a replication competent adenovirus engineered to replicate in tumor cells with an aberrant RB pathway. This virus has proven to be safe and effective in adult gliomas. Here we report that the administration of Delta-24-RGD is safe in mice and results in a significant increase in survival in immunodeficient and immunocompetent models of pHGG and DIPGs. Our results show that the Delta-24-RGD antiglioma effect is mediated by the oncolytic effect and the immune response elicited against the tumor. Altogether, our data highlight the potential of this virus as treatment for patients with these tumors. Of clinical significance, these data have led to the start of a phase I/II clinical trial at our institution for newly diagnosed DIPG (NCT03178032). | |
dc.format | Electronic | |
dc.format.extent | 2235 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Cell Line, Tumor | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Adenoviridae | |
dc.subject | Glioma | |
dc.subject | Brain Neoplasms | |
dc.subject | Brain Stem Neoplasms | |
dc.subject | Disease Models, Animal | |
dc.subject | Xenograft Model Antitumor Assays | |
dc.subject | Cell Survival | |
dc.subject | Computer Simulation | |
dc.subject | Oncolytic Virotherapy | |
dc.subject | Oncolytic Viruses | |
dc.subject | Neoplasm Grading | |
dc.subject | In Vitro Techniques | |
dc.title | The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-04-16 | |
rioxxterms.versionofrecord | 10.1038/s41467-019-10043-0 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-05-28 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Glioma Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Glioma Team | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Glioma Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Glioma Team | |
pubs.publication-status | Published | |
pubs.volume | 10 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Glioma Team | |
dc.contributor.icrauthor | Jones, Chris | |
dc.contributor.icrauthor | Mackay, Alan | |