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dc.contributor.authorBertholet, Jen_US
dc.contributor.authorKnopf, Aen_US
dc.contributor.authorEiben, Ben_US
dc.contributor.authorMcClelland, Jen_US
dc.contributor.authorGrimwood, Aen_US
dc.contributor.authorHarris, Een_US
dc.contributor.authorMenten, Men_US
dc.contributor.authorPoulsen, Pen_US
dc.contributor.authorNguyen, DTen_US
dc.contributor.authorKeall, Pen_US
dc.contributor.authorOelfke, Uen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-08-21T08:27:47Z
dc.date.issued2019-08-07en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31226704en_US
dc.identifier.citationPhys Med Biol, 2019, 64 (15), pp. 15TR01 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3328
dc.identifier.eissn1361-6560en_US
dc.identifier.doi10.1088/1361-6560/ab2ba8en_US
dc.description.abstractRadiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is constantly moving due to respiratory, cardiac, gastrointestinal and urinary activity. The long term goal of the RT community to 'see what we treat, as we treat' and to act on this information instantaneously has resulted in rapid technological innovation. Specialized treatment machines, such as robotic or gimbal-steered linear accelerators (linac) with in-room imaging suites, have been developed specifically for real-time treatment adaptation. Additional equipment, such as stereoscopic kilovoltage (kV) imaging, ultrasound transducers and electromagnetic transponders, has been developed for intrafraction motion monitoring on conventional linacs. Magnetic resonance imaging (MRI) has been integrated with cobalt treatment units and more recently with linacs. In addition to hardware innovation, software development has played a substantial role in the development of motion monitoring methods based on respiratory motion surrogates and planar kV or Megavoltage (MV) imaging that is available on standard equipped linacs. In this paper, we review and compare the different intrafraction motion monitoring methods proposed in the literature and demonstrated in real-time on clinical data as well as their possible future developments. We then discuss general considerations on validation and quality assurance for clinical implementation. Besides photon RT, particle therapy is increasingly used to treat moving targets. However, transferring motion monitoring technologies from linacs to particle beam lines presents substantial challenges. Lessons learned from the implementation of real-time intrafraction monitoring for photon RT will be used as a basis to discuss the implementation of these methods for particle RT.en_US
dc.format.extent15TR01 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleReal-time intrafraction motion monitoring in external beam radiotherapy.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1088/1361-6560/ab2ba8en_US
rioxxterms.licenseref.startdate2019-08-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfPhys Med Biolen_US
pubs.issue15en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Imaging for Radiotherapy Adaptation
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublished onlineen_US
pubs.volume64en_US
pubs.embargo.termsNot knownen_US
icr.researchteamImaging for Radiotherapy Adaptationen_US
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorOelfke, Uween_US
dc.contributor.icrauthorMenten, Martinen_US
dc.contributor.icrauthorGrimwood, Alexanderen_US
dc.contributor.icrauthorBertholet, Jennyen_US
dc.contributor.icrauthorMenten, Martinen_US
dc.contributor.icrauthorHarris, Emmaen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/