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dc.contributor.authorAlfieri, C
dc.contributor.authorZhang, S
dc.contributor.authorBarford, D
dc.date.accessioned2019-09-24T15:17:03Z
dc.date.issued2017-11
dc.identifier.citationOpen biology, 2017, 7 (11)
dc.identifier.issn2046-2441
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3364
dc.identifier.eissn2046-2441
dc.identifier.doi10.1098/rsob.170204
dc.description.abstractThe anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. During the two decades since its discovery, much has been learnt concerning its role in recognizing and ubiquitinating specific proteins in a cell-cycle-dependent manner, the mechanisms governing substrate specificity, the catalytic process of assembling polyubiquitin chains on its target proteins, and its regulation by phosphorylation and the spindle assembly checkpoint. The past few years have witnessed significant progress in understanding the quantitative mechanisms underlying these varied APC/C functions. This review integrates the overall functions and properties of the APC/C with mechanistic insights gained from recent cryo-electron microscopy (cryo-EM) studies of reconstituted human APC/C complexes.
dc.formatPrint
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectCell Cycle Proteins
dc.subjectCell Cycle
dc.subjectModels, Biological
dc.subjectAnaphase-Promoting Complex-Cyclosome
dc.titleVisualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
dc.typeJournal Article
dcterms.dateAccepted2017-10-10
rioxxterms.versionofrecord10.1098/rsob.170204
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfOpen biology
pubs.issue11
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Molecular mechanisms of cell cycle regulation
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Molecular mechanisms of cell cycle regulation
pubs.publication-statusPublished
pubs.volume7
pubs.embargo.termsNo embargo
icr.researchteamMolecular mechanisms of cell cycle regulationen_US
dc.contributor.icrauthorAlfieri, Claudioen


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