Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
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Date
2017-11-01ICR Author
Author
Alfieri, C
Zhang, S
Barford, D
Type
Journal Article
Metadata
Show full item recordAbstract
The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. During the two decades since its discovery, much has been learnt concerning its role in recognizing and ubiquitinating specific proteins in a cell-cycle-dependent manner, the mechanisms governing substrate specificity, the catalytic process of assembling polyubiquitin chains on its target proteins, and its regulation by phosphorylation and the spindle assembly checkpoint. The past few years have witnessed significant progress in understanding the quantitative mechanisms underlying these varied APC/C functions. This review integrates the overall functions and properties of the APC/C with mechanistic insights gained from recent cryo-electron microscopy (cryo-EM) studies of reconstituted human APC/C complexes.
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Subject
Cell Cycle Proteins
Cell Cycle
Models, Biological
Anaphase-Promoting Complex-Cyclosome
Research team
Molecular mechanisms of cell cycle regulation
Language
eng
Date accepted
2017-10-10
License start date
2017-11
Citation
Open biology, 2017, 7 (11)
Publisher
ROYAL SOC