dc.contributor.author | Szopa, W | |
dc.contributor.author | Burley, TA | |
dc.contributor.author | Kramer-Marek, G | |
dc.contributor.author | Kaspera, W | |
dc.date.accessioned | 2019-10-23T10:16:52Z | |
dc.date.issued | 2017-01-01 | |
dc.identifier.citation | BioMed research international, 2017, 2017 pp. 8013575 - ? | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3390 | |
dc.identifier.eissn | 2314-6141 | |
dc.identifier.doi | 10.1155/2017/8013575 | |
dc.description.abstract | Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system, characterized by an extremely aggressive clinical phenotype. Patients with GBM have a poor prognosis and only 3-5% of them survive for more than 5 years. The current GBM treatment standards include maximal resection followed by radiotherapy with concomitant and adjuvant therapies. Despite these aggressive therapeutic regimens, the majority of patients suffer recurrence due to molecular heterogeneity of GBM. Consequently, a number of potential diagnostic, prognostic, and predictive biomarkers have been investigated. Some of them, such as IDH mutations, 1p19q deletion, MGMT promoter methylation, and EGFRvIII amplification are frequently tested in routine clinical practice. With the development of sequencing technology, detailed characterization of GBM molecular signatures has facilitated a more personalized therapeutic approach and contributed to the development of a new generation of anti-GBM therapies such as molecular inhibitors targeting growth factor receptors, vaccines, antibody-based drug conjugates, and more recently inhibitors blocking the immune checkpoints. In this article, we review the exciting progress towards elucidating the potential of current and novel GBM biomarkers and discuss their implications for clinical practice. | |
dc.format | Print-Electronic | |
dc.format.extent | 8013575 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | HINDAWI LTD | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Immune System | |
dc.subject | Humans | |
dc.subject | Glioblastoma | |
dc.subject | Brain Neoplasms | |
dc.subject | Neoplasm Recurrence, Local | |
dc.subject | DNA Repair Enzymes | |
dc.subject | DNA Modification Methylases | |
dc.subject | Isocitrate Dehydrogenase | |
dc.subject | Tumor Suppressor Proteins | |
dc.subject | Prognosis | |
dc.subject | Medical Oncology | |
dc.subject | Signal Transduction | |
dc.subject | DNA Methylation | |
dc.subject | Gene Deletion | |
dc.subject | Phenotype | |
dc.subject | Mutation | |
dc.subject | Adult | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Promoter Regions, Genetic | |
dc.subject | ErbB Receptors | |
dc.subject | Biomarkers, Tumor | |
dc.title | Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-12-13 | |
rioxxterms.versionofrecord | 10.1155/2017/8013575 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2017-01 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | BioMed research international | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Preclinical Molecular Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Preclinical Molecular Imaging | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Preclinical Molecular Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Preclinical Molecular Imaging | |
pubs.publication-status | Published | |
pubs.volume | 2017 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Preclinical Molecular Imaging | |
dc.contributor.icrauthor | Burley, Thomas | |
dc.contributor.icrauthor | Kramer-Marek, Gabriela | |