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Prevalence, Impact, and Correlates of Severe Fatigue in Patients With Gastrointestinal Stromal Tumors.

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Date
2016-08
ICR Author
van der Graaf, Wilhelmina
Author
Poort, H
van der Graaf, WTA
Tielen, R
Vlenterie, M
Custers, JAE
Prins, JB
Verhagen, CAHHVM
Gielissen, MFM
Knoop, H
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Type
Journal Article
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Abstract
Context The introduction of the tyrosine kinase inhibitor (TKI) imatinib in the treatment of gastrointestinal stromal tumor (GIST) in 2000 was the start of a new era of targeted treatment. Since then, the median survival of patients with GIST has substantially increased. Prolonged survival and chronic TKI use are associated with treatment-induced symptoms, such as fatigue, which can compromise quality of life (QoL).Objectives This study determined the prevalence of severe fatigue in GIST patients compared to matched healthy controls, the impact of fatigue on daily life, and associations between fatigue and current TKI use.Methods One hundred nineteen patients treated with surgery and/or a TKI for GIST were asked to participate. Participants completed questionnaires including the Checklist Individual Strength-Fatigue Severity scale (CIS-fatigue), Short-Form 36-Item Health Survey, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30, Fatigue Catastrophizing Scale, Self-Efficacy Scale, and the Hospital Anxiety and Depression Scale.Results Eighty-nine GIST patients (75%) completed questionnaires, 61 patients (69%) were on a TKI. Prevalence of severe fatigue measured with CIS-fatigue was significantly higher in GIST patients (30%) than in 234 matched healthy controls (15%). The prevalence of severe fatigue did not differ significantly between patients receiving treatment with curative (29%) or palliative intent (36%). Severely fatigued patients reported lower QoL and more impairment on all functional domains. TKI use, more psychological distress, and lower physical functioning were associated with fatigue.Conclusion Severe fatigue occurs in 30% of GIST patients and in 33% of GIST patients on a TKI. The fatigue is disabling and is not only associated with current TKI use but also with psychological distress and physical functioning. GIST patients should be informed about these associated factors of fatigue that deserve appropriate management.
URI
https://repository.icr.ac.uk/handle/internal/343
DOI
https://doi.org/10.1016/j.jpainsymman.2016.02.019
Collections
  • Clinical Studies
Subject
Humans
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Fatigue
Protein Kinase Inhibitors
Severity of Illness Index
Prevalence
Cross-Sectional Studies
Quality of Life
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Young Adult
Research team
Clinical and Translational Sarcoma
Language
eng
Date accepted
2016-02-19
License start date
2016-08
Citation
Journal of pain and symptom management, 2016, 52 (2), pp. 265 - 271

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