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dc.contributor.authorGrootjans, Wen_US
dc.contributor.authorUsmanij, EAen_US
dc.contributor.authorOyen, WJGen_US
dc.contributor.authorvan der Heijden, EHFMen_US
dc.contributor.authorVisser, EPen_US
dc.contributor.authorVisvikis, Den_US
dc.contributor.authorHatt, Men_US
dc.contributor.authorBussink, Jen_US
dc.contributor.authorde Geus-Oei, L-Fen_US
dc.date.accessioned2016-12-19T15:11:55Z
dc.date.issued2016-06en_US
dc.identifier.citationRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, 119 (3), pp. 473 - 479en_US
dc.identifier.issn0167-8140en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/345
dc.identifier.eissn1879-0887en_US
dc.identifier.doi10.1016/j.radonc.2016.04.039en_US
dc.description.abstractThis study evaluated the use of total lesion glycolysis (TLG) determined by different automatic segmentation algorithms, for early response monitoring in non-small cell lung cancer (NSCLC) patients during concomitant chemoradiotherapy.Twenty-seven patients with locally advanced NSCLC treated with concomitant chemoradiotherapy underwent (18)F-fluorodeoxyglucose (FDG) PET/CT imaging before and in the second week of treatment. Segmentation of the primary tumours and lymph nodes was performed using fixed threshold segmentation at (i) 40% SUVmax (T40), (ii) 50% SUVmax (T50), (iii) relative-threshold-level (RTL), (iv) signal-to-background ratio (SBR), and (v) fuzzy locally adaptive Bayesian (FLAB) segmentation. Association of primary tumour TLG (TLGT), lymph node TLG (TLGLN), summed TLG (TLGS=TLGT+TLGLN), and relative TLG decrease (ΔTLG) with overall-survival (OS) and progression-free survival (PFS) was determined using univariate Cox regression models.Pretreatment TLGT was predictive for PFS and OS, irrespective of the segmentation method used. Inclusion of TLGLN improved disease and early response assessment, with pretreatment TLGS more strongly associated with PFS and OS than TLGT for all segmentation algorithms. This was also the case for ΔTLGS, which was significantly associated with PFS and OS, with the exception of RTL and T40.ΔTLGS was significantly associated with PFS and OS, except for RTL and T40. Inclusion of TLGLN improves early treatment response monitoring during concomitant chemoradiotherapy with FDG-PET.en_US
dc.formatPrint-Electronicen_US
dc.format.extent473 - 479en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectHumansen_US
dc.subjectCarcinoma, Non-Small-Cell Lungen_US
dc.subjectLung Neoplasmsen_US
dc.subjectFluorodeoxyglucose F18en_US
dc.subjectDisease-Free Survivalen_US
dc.subjectProportional Hazards Modelsen_US
dc.subjectBayes Theoremen_US
dc.subjectGlycolysisen_US
dc.subjectAlgorithmsen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectChemoradiotherapyen_US
dc.subjectPositron Emission Tomography Computed Tomographyen_US
dc.titlePerformance of automatic image segmentation algorithms for calculating total lesion glycolysis for early response monitoring in non-small cell lung cancer patients during concomitant chemoradiotherapy.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-04-16en_US
rioxxterms.versionofrecord10.1016/j.radonc.2016.04.039en_US
rioxxterms.licenseref.startdate2016-06en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.publication-statusPublisheden_US
pubs.volume119en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTranslational Molecular Imagingen_US
dc.contributor.icrauthorOyen, Willemen_US


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