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dc.contributor.authorDowney, K
dc.contributor.authorShepherd, JH
dc.contributor.authorAttygalle, AD
dc.contributor.authorHazell, S
dc.contributor.authorMorgan, VA
dc.contributor.authorGiles, SL
dc.contributor.authorInd, TEJ
dc.contributor.authorDesouza, NM
dc.date.accessioned2016-12-23T10:49:15Z
dc.date.issued2014-05
dc.identifier.citationGynecologic oncology, 2014, 133 (2), pp. 326 - 332
dc.identifier.issn0090-8258
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/348
dc.identifier.eissn1095-6859
dc.identifier.doi10.1016/j.ygyno.2014.02.026
dc.description.abstractAim The aim of this study is to validate high-resolution endovaginal T2- and diffusion-weighted MRI measurements (tumour size, volume and length of uninvolved cervical canal) against histology in patients undergoing trachelectomy.Patients/interventions 55 consecutive patients 25-44 years with cervical cancer being considered for trachelectomy were prospectively assessed with endovaginal T2-W and diffusion-weighted MRI. Two independent observers blinded to histology recorded maximum tumour dimension, volume and distance from the superior aspect of the tumour to the internal os. Following trachelectomy, pathologist-outlined tumour sections were photographed with a set scale and similar measurements were recorded.Results Fifteen of 45 patients subsequently treated with fertility-sparing surgery had residual tumour (median histological volume: 0.28 cm(3), IQR=0.14-1.06 cm(3)). Sensitivity, specificity, positive and negative predictive values for detecting tumour: Observer 1: 86.7%, 80.0%, 68.4%, and 92.3%, respectively; Observer 2: 86.7%, 90.0%, 81.0%, and 93.1%, respectively. Size and volume correlated between observers (r=0.96, 0.84, respectively, p<0.0001). Size correlated between each observer and histology (observer 1 r=0.91, p<0.0001; observer 2 r=0.93, p<0.0001), volume did not (observer 1: r=0.08, p=0.6; observer 2: r=0.21, p=0.16); however, differences between observer measurements and histology were not significant (size p=0.09, volume p=0.15). Differences between MRI and histology estimates of endocervical canal length were not significant (p=0.1 both observers).Conclusion In subcentimetre cervical cancers, endovaginal MRI correlates with pathology and is invaluable in assessing patients for fertility-sparing surgery.
dc.formatPrint-Electronic
dc.format.extent326 - 332
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectCervix Uteri
dc.subjectHumans
dc.subjectCarcinoma
dc.subjectMagnetic Resonance Imaging
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectPreoperative Care
dc.subjectHysterectomy
dc.subjectTumor Burden
dc.subjectSensitivity and Specificity
dc.subjectCohort Studies
dc.subjectAdult
dc.subjectUterine Cervical Neoplasms
dc.subjectFemale
dc.subjectOrgan Sparing Treatments
dc.subjectFertility Preservation
dc.titlePreoperative imaging in patients undergoing trachelectomy for cervical cancer: validation of a combined T2- and diffusion-weighted endovaginal MRI technique at 3.0 T.
dc.typeJournal Article
dcterms.dateAccepted2014-02-20
rioxxterms.versionofrecord10.1016/j.ygyno.2014.02.026
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2014-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfGynecologic oncology
pubs.issue2
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublished
pubs.volume133
pubs.embargo.termsNot known
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthordeSouza, Nanditaen
dc.contributor.icrauthorGiles, Sharonen


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