dc.contributor.author | Downey, K | |
dc.contributor.author | Shepherd, JH | |
dc.contributor.author | Attygalle, AD | |
dc.contributor.author | Hazell, S | |
dc.contributor.author | Morgan, VA | |
dc.contributor.author | Giles, SL | |
dc.contributor.author | Ind, TEJ | |
dc.contributor.author | Desouza, NM | |
dc.date.accessioned | 2016-12-23T10:49:15Z | |
dc.date.issued | 2014-05-01 | |
dc.identifier.citation | Gynecologic oncology, 2014, 133 (2), pp. 326 - 332 | |
dc.identifier.issn | 0090-8258 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/348 | |
dc.identifier.eissn | 1095-6859 | |
dc.identifier.doi | 10.1016/j.ygyno.2014.02.026 | |
dc.description.abstract | AIM: The aim of this study is to validate high-resolution endovaginal T2- and diffusion-weighted MRI measurements (tumour size, volume and length of uninvolved cervical canal) against histology in patients undergoing trachelectomy. PATIENTS/INTERVENTIONS: 55 consecutive patients 25-44 years with cervical cancer being considered for trachelectomy were prospectively assessed with endovaginal T2-W and diffusion-weighted MRI. Two independent observers blinded to histology recorded maximum tumour dimension, volume and distance from the superior aspect of the tumour to the internal os. Following trachelectomy, pathologist-outlined tumour sections were photographed with a set scale and similar measurements were recorded. RESULTS: Fifteen of 45 patients subsequently treated with fertility-sparing surgery had residual tumour (median histological volume: 0.28 cm(3), IQR=0.14-1.06 cm(3)). Sensitivity, specificity, positive and negative predictive values for detecting tumour: Observer 1: 86.7%, 80.0%, 68.4%, and 92.3%, respectively; Observer 2: 86.7%, 90.0%, 81.0%, and 93.1%, respectively. Size and volume correlated between observers (r=0.96, 0.84, respectively, p<0.0001). Size correlated between each observer and histology (observer 1 r=0.91, p<0.0001; observer 2 r=0.93, p<0.0001), volume did not (observer 1: r=0.08, p=0.6; observer 2: r=0.21, p=0.16); however, differences between observer measurements and histology were not significant (size p=0.09, volume p=0.15). Differences between MRI and histology estimates of endocervical canal length were not significant (p=0.1 both observers). CONCLUSION: In subcentimetre cervical cancers, endovaginal MRI correlates with pathology and is invaluable in assessing patients for fertility-sparing surgery. | |
dc.format | Print-Electronic | |
dc.format.extent | 326 - 332 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Cervix Uteri | |
dc.subject | Humans | |
dc.subject | Carcinoma | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Preoperative Care | |
dc.subject | Hysterectomy | |
dc.subject | Tumor Burden | |
dc.subject | Sensitivity and Specificity | |
dc.subject | Cohort Studies | |
dc.subject | Adult | |
dc.subject | Uterine Cervical Neoplasms | |
dc.subject | Female | |
dc.subject | Organ Sparing Treatments | |
dc.subject | Fertility Preservation | |
dc.title | Preoperative imaging in patients undergoing trachelectomy for cervical cancer: validation of a combined T2- and diffusion-weighted endovaginal MRI technique at 3.0 T. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2014-02-20 | |
rioxxterms.versionofrecord | 10.1016/j.ygyno.2014.02.026 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.licenseref.startdate | 2014-05 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Gynecologic oncology | |
pubs.issue | 2 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.publication-status | Published | |
pubs.volume | 133 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | deSouza, Nandita | |