dc.contributor.author | Yu, EY-W | |
dc.contributor.author | Nekeman, D | |
dc.contributor.author | Billingham, LJ | |
dc.contributor.author | James, ND | |
dc.contributor.author | Cheng, KK | |
dc.contributor.author | Bryan, RT | |
dc.contributor.author | Wesselius, A | |
dc.contributor.author | Zeegers, MP | |
dc.date.accessioned | 2020-02-04T12:05:06Z | |
dc.date.issued | 2019-12-01 | |
dc.identifier.citation | BJU international, 2019, 124 (6), pp. 984 - 991 | |
dc.identifier.issn | 1464-4096 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3506 | |
dc.identifier.eissn | 1464-410X | |
dc.identifier.doi | 10.1111/bju.14804 | |
dc.description.abstract | OBJECTIVES: To quantify the health-related quality of life (HRQoL) of patients with bladder cancer around the time of diagnosis and to test the hypotheses of a two-factor model for the HRQoL questionnaire QLQ-C30. METHODS: From participants in the Bladder Cancer Prognoses Programme, a multicentre cohort study, sociodemographic data were collected using semi-structured face-to-face interviews. Answers to the QLQ-C30 were transformed into a scale from 0 to 100. HRQoL data were analysed in multivariate analyses. The hypothesized two-factor (Physical and Mental Health) domain structure of the QLQ-C30 was also tested with confirmatory factor analyses (CFA). RESULTS: A total of 1160 participants (78%) completed the questionnaire after initial visual diagnosis and before pathological confirmation. Despite non-muscle-invasive bladder cancer (NMIBC) being associated with a higher HRQoL than carcinoma invading bladder muscle, only the domain Role Functioning was clinically significantly better in patients with NMIBC. Age, gender, bladder cancer stage and comorbidity all had a significant influence on QLQ-C30 scores. The CFA showed an overall good fit of the hypothesized two-factor model. CONCLUSION: This study identified a baseline reference value for HRQoL for patients with bladder cancer, which allows better evaluation of any changes in HRQoL as disease progresses or after treatment. In addition, a two-factor (Physical and Mental Health) model was developed for the QLQ-C30. | |
dc.format | Print-Electronic | |
dc.format.extent | 984 - 991 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Cohort Studies | |
dc.subject | Mental Health | |
dc.subject | Health Status | |
dc.subject | Time Factors | |
dc.subject | Quality of Life | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Urinary Bladder Neoplasms | |
dc.subject | Surveys and Questionnaires | |
dc.title | Health-related quality of life around the time of diagnosis in patients with bladder cancer. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1111/bju.14804 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | BJU international | |
pubs.issue | 6 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Prostate and Bladder Cancer Research | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Prostate and Bladder Cancer Research | |
pubs.publication-status | Published | |
pubs.volume | 124 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Prostate and Bladder Cancer Research | |
dc.contributor.icrauthor | James, Nicholas | |