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dc.contributor.authorDowney, Ken_US
dc.contributor.authorAttygalle, ADen_US
dc.contributor.authorMorgan, VAen_US
dc.contributor.authorGiles, SLen_US
dc.contributor.authorMacDonald, Aen_US
dc.contributor.authorDavis, Men_US
dc.contributor.authorInd, TEJen_US
dc.contributor.authorShepherd, JHen_US
dc.contributor.authordeSouza, NMen_US
dc.date.accessioned2016-12-23T11:00:38Z
dc.date.issued2016-04en_US
dc.identifier.citationEuropean radiology, 2016, 26 (4), pp. 941 - 950en_US
dc.identifier.issn0938-7994en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/350
dc.identifier.eissn1432-1084en_US
dc.identifier.doi10.1007/s00330-015-3899-5en_US
dc.description.abstract<h4>Objective</h4>To compare sensitivity and specificity of endovaginal versus external-array coil T2-W and T2-W + DWI for detecting and staging small cervical tumours.<h4>Methods</h4>Optimised endovaginal and external array coil MRI at 3.0-T was done prospectively in 48 consecutive patients with stage Ia/Ib1 cervical cancer. Sensitivity/specificity for detecting tumour and parametrial extension against histopathology for a reading radiologist were determined on coronal T2-W and T2W + DW images. An independent radiologist also scored T2-W images without and with addition of DWI for the external-array and endovaginal coils on separate occasions >2 weeks apart. Cohen's kappa assessed inter- and intra-observer agreement.<h4>Results</h4>Median tumour volume in 19/38 cases positive on subsequent histology was 1.75 cm(3). Sensitivity, specificity, PPV, NPV were: reading radiologist 91.3 %, 89.5 %, 91.3 %, 89.5 %, respectively; independent radiologist T2-W 82.6 %, 73.7 %, 79.1 %, 77.8 % for endovaginal, 73.9 %, 89.5 %, 89.5 %, 73.9 % for external-array coil. Adding DWI improved sensitivity and specificity of endovaginal imaging (78.2 %, 89.5 %); adding DWI to external-array imaging improved specificity (94.7 %) but reduced sensitivity (66.7 %). Inter- and intra-observer agreement on T2-W + DWI was good (kappa = 0.67 and 0.62, respectively).<h4>Conclusion</h4>Endovaginal coil T2-W MRI is more sensitive than external-array coil for detecting tumours <2 cm(3); adding DWI improves specificity of endovaginal imaging but reduces sensitivity of external-array imaging.<h4>Key points</h4>• Endovaginal more accurate than external-array T2-W MRI for detecting small cervical cancers. • Addition of DWI improves sensitivity and specificity of endovaginal T2-W imaging. • Addition of DWI substantially reduces sensitivity of external-array T2-W imaging.en_US
dc.formatPrint-Electronicen_US
dc.format.extent941 - 950en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectHumansen_US
dc.subjectObserver Variationen_US
dc.subjectDiffusion Magnetic Resonance Imagingen_US
dc.subjectNeoplasm Stagingen_US
dc.subjectTumor Burdenen_US
dc.subjectSensitivity and Specificityen_US
dc.subjectProspective Studiesen_US
dc.subjectAdulten_US
dc.subjectMiddle Ageden_US
dc.subjectUterine Cervical Neoplasmsen_US
dc.subjectFemaleen_US
dc.subjectEarly Detection of Canceren_US
dc.titleComparison of optimised endovaginal vs external array coil T2-weighted and diffusion-weighted imaging techniques for detecting suspected early stage (IA/IB1) uterine cervical cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2015-06-22en_US
rioxxterms.versionofrecord10.1007/s00330-015-3899-5en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
rioxxterms.licenseref.startdate2016-04en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfEuropean radiologyen_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublisheden_US
pubs.volume26en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthordeSouza, Nanditaen_US
dc.contributor.icrauthorGiles, Sharonen_US


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