dc.contributor.author | Downey, K | |
dc.contributor.author | Attygalle, AD | |
dc.contributor.author | Morgan, VA | |
dc.contributor.author | Giles, SL | |
dc.contributor.author | MacDonald, A | |
dc.contributor.author | Davis, M | |
dc.contributor.author | Ind, TEJ | |
dc.contributor.author | Shepherd, JH | |
dc.contributor.author | deSouza, NM | |
dc.date.accessioned | 2016-12-23T11:00:38Z | |
dc.date.issued | 2016-04-01 | |
dc.identifier.citation | European radiology, 2016, 26 (4), pp. 941 - 950 | |
dc.identifier.issn | 0938-7994 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/350 | |
dc.identifier.eissn | 1432-1084 | |
dc.identifier.doi | 10.1007/s00330-015-3899-5 | |
dc.description.abstract | OBJECTIVE: To compare sensitivity and specificity of endovaginal versus external-array coil T2-W and T2-W + DWI for detecting and staging small cervical tumours. METHODS: Optimised endovaginal and external array coil MRI at 3.0-T was done prospectively in 48 consecutive patients with stage Ia/Ib1 cervical cancer. Sensitivity/specificity for detecting tumour and parametrial extension against histopathology for a reading radiologist were determined on coronal T2-W and T2W + DW images. An independent radiologist also scored T2-W images without and with addition of DWI for the external-array and endovaginal coils on separate occasions >2 weeks apart. Cohen's kappa assessed inter- and intra-observer agreement. RESULTS: Median tumour volume in 19/38 cases positive on subsequent histology was 1.75 cm(3). Sensitivity, specificity, PPV, NPV were: reading radiologist 91.3 %, 89.5 %, 91.3 %, 89.5 %, respectively; independent radiologist T2-W 82.6 %, 73.7 %, 79.1 %, 77.8 % for endovaginal, 73.9 %, 89.5 %, 89.5 %, 73.9 % for external-array coil. Adding DWI improved sensitivity and specificity of endovaginal imaging (78.2 %, 89.5 %); adding DWI to external-array imaging improved specificity (94.7 %) but reduced sensitivity (66.7 %). Inter- and intra-observer agreement on T2-W + DWI was good (kappa = 0.67 and 0.62, respectively). CONCLUSION: Endovaginal coil T2-W MRI is more sensitive than external-array coil for detecting tumours <2 cm(3); adding DWI improves specificity of endovaginal imaging but reduces sensitivity of external-array imaging. KEY POINTS: • Endovaginal more accurate than external-array T2-W MRI for detecting small cervical cancers. • Addition of DWI improves sensitivity and specificity of endovaginal T2-W imaging. • Addition of DWI substantially reduces sensitivity of external-array T2-W imaging. | |
dc.format | Print-Electronic | |
dc.format.extent | 941 - 950 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SPRINGER | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
dc.subject | Humans | |
dc.subject | Observer Variation | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Neoplasm Staging | |
dc.subject | Tumor Burden | |
dc.subject | Sensitivity and Specificity | |
dc.subject | Prospective Studies | |
dc.subject | Adult | |
dc.subject | Middle Aged | |
dc.subject | Uterine Cervical Neoplasms | |
dc.subject | Female | |
dc.subject | Early Detection of Cancer | |
dc.title | Comparison of optimised endovaginal vs external array coil T2-weighted and diffusion-weighted imaging techniques for detecting suspected early stage (IA/IB1) uterine cervical cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2015-06-22 | |
rioxxterms.versionofrecord | 10.1007/s00330-015-3899-5 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
rioxxterms.licenseref.startdate | 2016-04 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | European radiology | |
pubs.issue | 4 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.publication-status | Published | |
pubs.volume | 26 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | deSouza, Nandita | |