dc.contributor.author | deSouza, NM | |
dc.contributor.author | Orton, M | |
dc.contributor.author | Downey, K | |
dc.contributor.author | Morgan, VA | |
dc.contributor.author | Collins, DJ | |
dc.contributor.author | Giles, SL | |
dc.contributor.author | Payne, GS | |
dc.date.accessioned | 2016-12-23T11:02:14Z | |
dc.date.issued | 2016-05-01 | |
dc.identifier.citation | Journal of magnetic resonance imaging : JMRI, 2016, 43 (5), pp. 1218 - 1223 | |
dc.identifier.issn | 1053-1807 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/351 | |
dc.identifier.eissn | 1522-2586 | |
dc.identifier.doi | 10.1002/jmri.25080 | |
dc.description.abstract | PURPOSE: To investigate the clinical utility of the reverse gradient algorithm in correcting distortions in diffusion-weighted images of the cervix and for increasing diagnostic performance. MATERIALS AND METHODS: Forty-one patients ages 25-72 years (mean 40 ± 11 years) with suspected or early stage cervical cancer were imaged at 3T using an endovaginal coil. T2 -weighted (W) and diffusion-weighted images with right and left phase-encode gradient directions were obtained coronal to the cervix (b = 0, 100, 300, 500, 800 s mm(-2) ). Differences in angle of the endocervical canal to the x-axis between T2 W and right-gradient, left-gradient, and corrected images were measured. Uncorrected and corrected images were assessed for diagnostic performance when viewed together with T2 W images by two independent observers against subsequent histology. RESULTS: The angles of the endocervical canal relative to the x-axis were significantly different between the T2 W images and the right-gradient images (P = 0.007), approached significance for left-gradient images (P = 0.055), and were not significantly different after correction (P = 0.95). Corrected images enabled a definitive diagnosis in 34% (n = 14) of patients classified as equivocal on uncorrected images. Tumor volume in this subset was 0.18 ± 0.44 cm(3) (mean ± SD; sensitivity of detection 100% [8/8], specificity 50% [3/6] for an experienced observer). Correction did not improve diagnostic performance for the less-experienced observer. CONCLUSION: Distortion-corrected diffusion-weighted images improved correspondence with T2 W images and diagnostic performance in a third of cases. | |
dc.format | Print-Electronic | |
dc.format.extent | 1218 - 1223 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY-BLACKWELL | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Cervix Uteri | |
dc.subject | Humans | |
dc.subject | Observer Variation | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Echo-Planar Imaging | |
dc.subject | Prospective Studies | |
dc.subject | Algorithms | |
dc.subject | Image Processing, Computer-Assisted | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Uterine Cervical Neoplasms | |
dc.subject | Female | |
dc.subject | Male | |
dc.title | Distortion correction of echo-planar diffusion-weighted images of uterine cervix. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2015-10-06 | |
rioxxterms.versionofrecord | 10.1002/jmri.25080 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-05 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Journal of magnetic resonance imaging : JMRI | |
pubs.issue | 5 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.publication-status | Published | |
pubs.volume | 43 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | deSouza, Nandita | |
dc.contributor.icrauthor | Collins, David | |