dc.contributor.author | Pace, E | |
dc.contributor.author | MacKinnon, AD | |
dc.contributor.author | deSouza, NM | |
dc.date.accessioned | 2020-04-09T10:39:15Z | |
dc.date.issued | 2020-09-01 | |
dc.identifier.citation | Acta radiologica (Stockholm, Sweden : 1987), 2020, 61 (9), pp. 1240 - 1248 | |
dc.identifier.issn | 0284-1851 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3586 | |
dc.identifier.eissn | 1600-0455 | |
dc.identifier.doi | 10.1177/0284185119894217 | |
dc.description.abstract | BACKGROUND: Bone marrow composition varies with stage of development. PURPOSE: To assess differences in apparent diffusion coefficient (ADC) derived from clivus bone marrow in healthy children by age, pubertal status, and gender as a benchmark when monitoring local and systemic treatment-induced effects. MATERIAL AND METHODS: Non-oncological pediatric patients (30 pre-pubertal [15 girls, 15 boys] and 30 post-pubertal [15 girls, 15 boys]) with previous normal magnetic resonance imaging (MRI) of the brain including diffusion-weighted magnetic resonance imaging (DW-MRI; 1.5-T Philips Achieva-Ingenia, b-values 0 and 1000s/mm2) were studied. A 4-6 mm diameter region of interest (ROI), drawn within the clivus on two or three DW-MRI slices, yielded mean and centile ADC values. Pubertal status was recognized from imaging appearances of the pituitary gland and from fusion of the spheno-occipital synchondrosis. Correlations between ADC and age were assessed (Pearson's coefficient). Mann-Whitney U tests compared ADC by age, pubertal status, and gender. RESULTS: Age and ADC were significantly negatively correlated (median ADC r=-0.48, mean ADC r=-0.42, P=0.0001 and 0.0008, respectively) which held true when divided by gender. Mean and median ADC differed significantly before and after puberty for the whole population (P=0.0001 and 0.0001, respectively). There was a left shift of the ADC histogram after puberty with significant differences in centile values. ADC differences before and after puberty remained when divided by gender (girls: P=0.04 and 0.009, respectively; boys: P=0.005 and 0.0002, respectively). CONCLUSION: ADC of clivus bone marrow correlates with age in children. ADC decreases significantly after puberty, likely due to replacement of hypercellular marrow with fat. There are no gender-related differences in clivus bone-marrow ADC before or after puberty. | |
dc.format | Print-Electronic | |
dc.format.extent | 1240 - 1248 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SAGE PUBLICATIONS LTD | |
dc.rights.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
dc.subject | Skull | |
dc.subject | Bone Marrow | |
dc.subject | Humans | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Sex Factors | |
dc.subject | Adolescent | |
dc.subject | Child | |
dc.subject | Child, Preschool | |
dc.subject | Female | |
dc.subject | Male | |
dc.title | Variation of the apparent diffusion coefficient of skull bone marrow by age group, pubertal status, and gender in a pediatric population. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1177/0284185119894217 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2020-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Acta radiologica (Stockholm, Sweden : 1987) | |
pubs.issue | 9 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.publication-status | Published | |
pubs.volume | 61 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | deSouza, Nandita | |