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dc.contributor.authorSzychot, Een_US
dc.contributor.authorSeunarine, KKen_US
dc.contributor.authorRobles, CAen_US
dc.contributor.authorMandeville, Hen_US
dc.contributor.authorMankad, Ken_US
dc.contributor.authorClark, Cen_US
dc.contributor.authorPeregud-Pogorzelski, Jen_US
dc.contributor.authorDesouza, Nen_US
dc.date.accessioned2020-05-21T11:12:29Z
dc.date.issued2020-03en_US
dc.identifier.citationAdvances in clinical and experimental medicine : official organ Wroclaw Medical University, 2020, 29 (3), pp. 331 - 337en_US
dc.identifier.issn1899-5276en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3620
dc.identifier.doi10.17219/acem/114827en_US
dc.description.abstractBACKGROUND:More than half of pediatric tumors of central nervous system (CNS) primarily originate in the posterior fossa and are conventionally treated with radiation therapy (RT). OBJECTIVES:The objective of this study was to establish whether corpus callosum volumes (CCV) and whole brain volumes (WBV) are correlated and to determine the impact of whole-brain lowvs high-dose RT on brain parenchymal volume loss as assessed using each technique. MATERIAL AND METHODS:Of the 30 identified children (6-12 years) with newly diagnosed posterior fossa tumors treated with cranial RT, including focal and whole-brain RT, suitable imaging was obtained for 23. Radiotherapy regimens were the following: no whole-brain RT (Group 1, n = 7), low-dose whole-brain RT (<30 Gy, Group 2, n = 9) and high-dose whole-brain RT (>30 Gy, Group 3, n = 7) in addition to focal boost. Magnetic resonance images (MRIs) were analyzed at baseline and follow-up (median 14 months). The CCVs were manually segmented on midline sagittal slice (n = 23), while WBVs were segmented semi-automatically using Freesurfer (n = 15). This was done twice (6-month interval) for all baseline CCV measurements and 5 randomly selected WBV measurements to establish measurement reproducibility. Correlations between CCV and WBV were investigated and percentage of children demonstrating reduction in CCV or WBV noted. RESULTS:Correlation between baseline CCV and WBV was not significant (p = 0.37). Measurement reproducibility was from 6% to -9% for CCV and from 4.8% to -1.2% for WBV. Among the children studied, 30.4% (7/23) had >9% reduction in CCV at follow-up, while 33.3% (5/15) had >1.2% reduction in WBV. Five of 7 patients with CCV loss were not picked up by WBV measurements. Similarly, 3 of 5 patients with WBV loss were not picked up by CCV measurements. CONCLUSIONS:The CCV and the WBV are unrelated and may indicate different brain parenchymal losses following RT. Up to a third of posterior fossa tumors treated with RT have measurable CCV or WBV loss; incidence was equivalent in lowvs high-dose whole-brain RT.en_US
dc.formatPrinten_US
dc.format.extent331 - 337en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleEstimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children).en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.17219/acem/114827en_US
rioxxterms.licenseref.startdate2020-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfAdvances in clinical and experimental medicine : official organ Wroclaw Medical Universityen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy for Children, Teenagers and Young Adults
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume29en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMagnetic Resonanceen_US
icr.researchteamRadiotherapy for Children, Teenagers and Young Adultsen_US
dc.contributor.icrauthordeSouza, Nanditaen_US
dc.contributor.icrauthorMandeville, Henryen_US


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