dc.contributor.author | Szychot, E | |
dc.contributor.author | Seunarine, KK | |
dc.contributor.author | Robles, CA | |
dc.contributor.author | Mandeville, H | |
dc.contributor.author | Mankad, K | |
dc.contributor.author | Clark, C | |
dc.contributor.author | Peregud-Pogorzelski, J | |
dc.contributor.author | Desouza, N | |
dc.date.accessioned | 2020-05-21T11:12:29Z | |
dc.date.issued | 2020-03-01 | |
dc.identifier.citation | Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2020, 29 (3), pp. 331 - 337 | |
dc.identifier.issn | 1899-5276 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3620 | |
dc.identifier.doi | 10.17219/acem/114827 | |
dc.description.abstract | BACKGROUND: More than half of pediatric tumors of central nervous system (CNS) primarily originate in the posterior fossa and are conventionally treated with radiation therapy (RT). OBJECTIVES: The objective of this study was to establish whether corpus callosum volumes (CCV) and whole brain volumes (WBV) are correlated and to determine the impact of whole-brain lowvs high-dose RT on brain parenchymal volume loss as assessed using each technique. MATERIAL AND METHODS: Of the 30 identified children (6-12 years) with newly diagnosed posterior fossa tumors treated with cranial RT, including focal and whole-brain RT, suitable imaging was obtained for 23. Radiotherapy regimens were the following: no whole-brain RT (Group 1, n = 7), low-dose whole-brain RT (<30 Gy, Group 2, n = 9) and high-dose whole-brain RT (>30 Gy, Group 3, n = 7) in addition to focal boost. Magnetic resonance images (MRIs) were analyzed at baseline and follow-up (median 14 months). The CCVs were manually segmented on midline sagittal slice (n = 23), while WBVs were segmented semi-automatically using Freesurfer (n = 15). This was done twice (6-month interval) for all baseline CCV measurements and 5 randomly selected WBV measurements to establish measurement reproducibility. Correlations between CCV and WBV were investigated and percentage of children demonstrating reduction in CCV or WBV noted. RESULTS: Correlation between baseline CCV and WBV was not significant (p = 0.37). Measurement reproducibility was from 6% to -9% for CCV and from 4.8% to -1.2% for WBV. Among the children studied, 30.4% (7/23) had >9% reduction in CCV at follow-up, while 33.3% (5/15) had >1.2% reduction in WBV. Five of 7 patients with CCV loss were not picked up by WBV measurements. Similarly, 3 of 5 patients with WBV loss were not picked up by CCV measurements. CONCLUSIONS: The CCV and the WBV are unrelated and may indicate different brain parenchymal losses following RT. Up to a third of posterior fossa tumors treated with RT have measurable CCV or WBV loss; incidence was equivalent in lowvs high-dose whole-brain RT. | |
dc.format | Print | |
dc.format.extent | 331 - 337 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WROCLAW MEDICAL UNIV | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Brain | |
dc.subject | Corpus Callosum | |
dc.subject | Humans | |
dc.subject | Brain Neoplasms | |
dc.subject | Infratentorial Neoplasms | |
dc.subject | Organ Size | |
dc.subject | Radiotherapy | |
dc.subject | Reproducibility of Results | |
dc.subject | Child | |
dc.title | Estimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children). | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.17219/acem/114827 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2020-03 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Advances in clinical and experimental medicine : official organ Wroclaw Medical University | |
pubs.issue | 3 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Paediatric and Adolescent Radiotherapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Paediatric and Adolescent Radiotherapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 29 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Magnetic Resonance | |
icr.researchteam | Paediatric and Adolescent Radiotherapy | |
dc.contributor.icrauthor | deSouza, Nandita | |