Public resources for chemical probes: the journey so far and the road ahead.
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Date
2019-11-28Author
Antolin, AA
Workman, P
Al-Lazikani, B
Type
Journal Article
Metadata
Show full item recordAbstract
High-quality small molecule chemical probes are extremely valuable for biological research and target validation. However, frequent use of flawed small-molecule inhibitors produces misleading results and diminishes the robustness of biomedical research. Several public resources are available to facilitate assessment and selection of better chemical probes for specific protein targets. Here, we review chemical probe resources, discuss their current strengths and limitations, and make recommendations for further improvements. Expert review resources provide in-depth analysis but currently cover only a limited portion of the liganded proteome. Computational resources encompass more proteins and are regularly updated, but have limitations in data availability and curation. We show how biomedical scientists may use these resources to choose the best available chemical probes for their research.
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Research team
Computational Biology and Chemogenomics
Language
eng
Date accepted
2019-09-30
License start date
2019-11-28
Citation
Future medicinal chemistry, 2019
Publisher
Future Science Ltd