dc.contributor.author | Jerome, NP | |
dc.contributor.author | d'Arcy, JA | |
dc.contributor.author | Feiweier, T | |
dc.contributor.author | Koh, D-M | |
dc.contributor.author | Leach, MO | |
dc.contributor.author | Collins, DJ | |
dc.contributor.author | Orton, MR | |
dc.date.accessioned | 2017-01-05T11:18:53Z | |
dc.date.issued | 2016-12-21 | |
dc.identifier.citation | Physics in medicine and biology, 2016, 61 (24), pp. N667 - N680 | |
dc.identifier.issn | 0031-9155 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/373 | |
dc.identifier.eissn | 1361-6560 | |
dc.identifier.doi | 10.1088/1361-6560/61/24/n667 | |
dc.description.abstract | The bi-exponential intravoxel-incoherent-motion (IVIM) model for diffusion-weighted MRI (DWI) fails to account for differential T 2 s in the model compartments, resulting in overestimation of pseudodiffusion fraction f. An extended model, T2-IVIM, allows removal of the confounding echo-time (TE) dependence of f, and provides direct compartment T 2 estimates. Two consented healthy volunteer cohorts (n = 5, 6) underwent DWI comprising multiple TE/b-value combinations (Protocol 1: TE = 62-102 ms, b = 0-250 mm-2s, 30 combinations. Protocol 2: 8 b-values 0-800 mm-2s at TE = 62 ms, with 3 additional b-values 0-50 mm-2s at TE = 80, 100 ms; scanned twice). Data from liver ROIs were fitted with IVIM at individual TEs, and with the T2-IVIM model using all data. Repeat-measures coefficients of variation were assessed for Protocol 2. Conventional IVIM modelling at individual TEs (Protocol 1) demonstrated apparent f increasing with longer TE: 22.4 ± 7% (TE = 62 ms) to 30.7 ± 11% (TE = 102 ms); T2-IVIM model fitting accounted for all data variation. Fitting of Protocol 2 data using T2-IVIM yielded reduced f estimates (IVIM: 27.9 ± 6%, T2-IVIM: 18.3 ± 7%), as well as T 2 = 42.1 ± 7 ms, 77.6 ± 30 ms for true and pseudodiffusion compartments, respectively. A reduced Protocol 2 dataset yielded comparable results in a clinical time frame (11 min). The confounding dependence of IVIM f on TE can be accounted for using additional b/TE images and the extended T2-IVIM model. | |
dc.format | Print-Electronic | |
dc.format.extent | N667 - N680 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | IOP PUBLISHING LTD | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Liver | |
dc.subject | Humans | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Prospective Studies | |
dc.subject | Reproducibility of Results | |
dc.subject | Models, Theoretical | |
dc.subject | Adult | |
dc.subject | Middle Aged | |
dc.title | Extended T2-IVIM model for correction of TE dependence of pseudo-diffusion volume fraction in clinical diffusion-weighted magnetic resonance imaging. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1088/1361-6560/61/24/n667 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Physics in medicine and biology | |
pubs.issue | 24 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 61 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | Leach, Martin | |
dc.contributor.icrauthor | Collins, David | |