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dc.contributor.authorJerome, NP
dc.contributor.authord'Arcy, JA
dc.contributor.authorFeiweier, T
dc.contributor.authorKoh, D-M
dc.contributor.authorLeach, MO
dc.contributor.authorCollins, DJ
dc.contributor.authorOrton, MR
dc.date.accessioned2017-01-05T11:18:53Z
dc.date.issued2016-12-21
dc.identifier.citationPhysics in medicine and biology, 2016, 61 (24), pp. N667 - N680
dc.identifier.issn0031-9155
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/373
dc.identifier.eissn1361-6560
dc.identifier.doi10.1088/1361-6560/61/24/n667
dc.description.abstractThe bi-exponential intravoxel-incoherent-motion (IVIM) model for diffusion-weighted MRI (DWI) fails to account for differential T 2 s in the model compartments, resulting in overestimation of pseudodiffusion fraction f. An extended model, T2-IVIM, allows removal of the confounding echo-time (TE) dependence of f, and provides direct compartment T 2 estimates. Two consented healthy volunteer cohorts (n  =  5, 6) underwent DWI comprising multiple TE/b-value combinations (Protocol 1: TE  =  62-102 ms, b  =  0-250 mm-2s, 30 combinations. Protocol 2: 8 b-values 0-800 mm-2s at TE  =  62 ms, with 3 additional b-values 0-50 mm-2s at TE  =  80, 100 ms; scanned twice). Data from liver ROIs were fitted with IVIM at individual TEs, and with the T2-IVIM model using all data. Repeat-measures coefficients of variation were assessed for Protocol 2. Conventional IVIM modelling at individual TEs (Protocol 1) demonstrated apparent f increasing with longer TE: 22.4  ±  7% (TE  =  62 ms) to 30.7  ±  11% (TE  =  102 ms); T2-IVIM model fitting accounted for all data variation. Fitting of Protocol 2 data using T2-IVIM yielded reduced f estimates (IVIM: 27.9  ±  6%, T2-IVIM: 18.3  ±  7%), as well as T 2  =  42.1  ±  7 ms, 77.6  ±  30 ms for true and pseudodiffusion compartments, respectively. A reduced Protocol 2 dataset yielded comparable results in a clinical time frame (11 min). The confounding dependence of IVIM f on TE can be accounted for using additional b/TE images and the extended T2-IVIM model.
dc.formatPrint-Electronic
dc.format.extentN667 - N680
dc.languageeng
dc.language.isoeng
dc.publisherIOP PUBLISHING LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectLiver
dc.subjectHumans
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectProspective Studies
dc.subjectReproducibility of Results
dc.subjectModels, Theoretical
dc.subjectAdult
dc.subjectMiddle Aged
dc.titleExtended T2-IVIM model for correction of TE dependence of pseudo-diffusion volume fraction in clinical diffusion-weighted magnetic resonance imaging.
dc.typeJournal Article
rioxxterms.versionofrecord10.1088/1361-6560/61/24/n667
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPhysics in medicine and biology
pubs.issue24
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume61
pubs.embargo.termsNo embargo
icr.researchteamMagnetic Resonance
dc.contributor.icrauthorLeach, Martin
dc.contributor.icrauthorCollins, David


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